SCM error: Multiple instances of label in problem to update

Dear all, I am running the SCM tool in PsN but I am getting the following error: "Multiple instances of label [P]_ in problem to update, ambiguous parameter matching by label. at C:\Perl64\site\lib/PsN_4_2_0/model.pm line 3424." This is a 2 compartment model with oral absorption (ADVAN 4) parameterized in CL and Q (i.e.: TRANS 4) with lag time. Here is the scm config file: model=125_COV.ctl directory=scm-both-125 search_direction=both only_successful=1 parallel_states=1 p_forward=0.05 p_backward=0.01 continuous_covariates=WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL categorical_covariates=SEXF do_not_drop=WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL,SEXF missing_data_token=-99 linearize=0 nm_version=default retries=2 threads=4 [test_relations] CL= SEXF,WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL V2= SEXF,WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL [valid_states] continuous = 1,5 catagorical=1,2 Many thanks in advance for your help. Amir

Dear Amir, I believe this occurs when you have multiple values with the same (commented) label. Eg $Theta ... (0, 10) ; [P] cov_cl (0, 1.2) ; [P] cov_cl ... In your case specifically you may have two with the label "[P]_" therefore just adding an additional character to either of those should resolve the issue. Devin Pastoor Center for Translational Medicine University of Maryland, Baltimore

All, Devin Pastoor is right. I can add that PsN-4.4.0 takes care of the label change automatically. Best regards, Kajsa Harling On 05/01/2015 06:10 PM, Devin Pastoor wrote: Dear Amir, I believe this occurs when you have multiple values with the same (commented) label. Eg $Theta ... (0, 10) ; [P] cov_cl (0, 1.2) ; [P] cov_cl ... In your case specifically you may have two with the label " [P]_" therefore just adding an additional character to either of those should resolve the issue. Devin Pastoor Center for Translational Medicine University of Maryland, Baltimore On Fri, May 1, 2015 at 12:00 PM Amir Youssef < [email protected] > wrote: Dear all, I am running the SCM tool in PsN but I am getting the following error: "Multiple instances of label [P]_ in problem to update, ambiguous parameter matching by label. at C:\Perl64\site\lib/PsN_4_2_0/ model.pm line 3424." This is a 2 compartment model with oral absorption (ADVAN 4) parameterized in CL and Q (i.e.: TRANS 4) with lag time. Here is the scm config file: model=125_COV.ctl directory=scm-both-125 search_direction=both _only_successful_=1 parallel_states=1 p_forward=0.05 p_backward=0.01 continuous_covariates=WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL categorical_covariates=SEXF do_not_drop=WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL,SEXF missing_data_token=-99 linearize=0 nm_version=default retries=2 threads=4 [test_relations] CL= SEXF,WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL V2= SEXF,WTKG,HTCM,BMIKGM2,AGEYR,TBILIUM,ASTUL,ALTUL,GGTUL,ALPUL,CRUM,BUNMM,UACUM,UPGL,ECRCL [valid_states] continuous = 1,5 catagorical=1,2 Many thanks in advance for your help. Amir -- ----------------------------------------------------------------- Kajsa Harling, PhD System Developer Department of Pharmaceutical Biosciences Uppsala University [email protected] +46-(0)18-471 4308 http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/