Dear All,
I have a data file that I would like to fit into other people's model
(using their THETA values to run my datafile) to see how good the
predictions are.
I have switched to SAEM from FOCE due to non-convergence issue for my base
model, therefore I would like to use SAEM method to evaluate model fitting
with published models for a fair comparison. When I tried the same
MAXEVAL=0 with SAEM, I have got an error message on MAXEVAL must be at
least 1 with SAEM. There are very little discussion on this topic with
SAEM. Can anyone please shed some light on any work around? If there is no
work around for using published model's THETA values to run my data file
with SAEM, how should I create a fair comparison to compare my SAEM base
model with published models that are run on FOCE?
Thank you.
Kind regards,
Andrew Tse
Research Pharmacist
SAEM with MAXEVAL= 0 possible? or any work around?
Hi Andrew,
SAEM equivalent of MAXEVAL=0 would be EONLY=1
Results should not depend on the method so you should be safe just using FOCEI for model evalaution. Also, what was the problem with "non-convergence of the base model", was it just error code 134? If the model is stable (solution does not depend on initial conditions, RSEs are reasonable) then error code 134 is not a real problem, you can continue to use FOCEI with that. Often, it helps to clean the date and remove obvious outliers (makes model more stable and more likely to converge).
Thanks
Leonid
Quoted reply history
On 3/4/2019 9:56 PM, Andrew Tse wrote:
> Dear All,
>
> I have a data file that I would like to fit into other people's model (using their THETA values to run my datafile) to see how good the predictions are. I have switched to SAEM from FOCE due to non-convergence issue for my base model, therefore I would like to use SAEM method to evaluate model fitting with published models for a fair comparison. When I tried the same MAXEVAL=0 with SAEM, I have got an error message on MAXEVAL must be at least 1 with SAEM. There are very little discussion on this topic with SAEM. Can anyone please shed some light on any work around? If there is no work around for using published model's THETA values to run my data file with SAEM, how should I create a fair comparison to compare my SAEM base model with published models that are run on FOCE?
>
> Thank you.
>
> Kind regards,
> Andrew Tse
>
> Research Pharmacist