From BRUCE@uqpharmacy.pharmacy.uq.edu.au Fri Aug 25 00:52:16 1995
Subject: Residuals in NONMEM
Hi NM-users,
Can anybody clear up the following for us?
We are assessing predictive performance of a "best" NONMEM model using POSTHOC Bayesian estimation in an independent group of subjects. Are the weighted residuals (WRES) produced by POSTHOC equivalent to the "Standardised Residuals" (SRES) used, e.g. by Sam Vozeh's group for this purpose (e.g. see J Pharmacokinet Biopharm 1990;18:161-173, and Clin Pharmacol Ther 1991;50:55-65)?
If they are then the mean of the WRES apparently can be t-tested against 0, and the standard deviation of the SRES can be t-tested against 1. Is our thinking on this correct? Thanks in anticipation of any advice.
Best wishes,
Bruce Charles
Pharmacy Dept, Univ Qld,
Brisbane, Australia