Dear Dr. Bachman,
My thinking was that the amount in these compartments is "emptied" i.e. set to
zero and turned off (and hence the CMT needs to turned back on again). There
are some nice postings by Drs. Karlsson and Gibiansky on how to "empty" the
urine compartment when modeling urine sample collection interval data and
plasma PK data simultaneously.
http://www.cognigencorp.com/nonmem/nm/99jun152004.html
I have also used this trick to model transdermal patch data. The patch is
removed after a fixed time, so the time point when the patch is removed the
absorption compartment should be emptied (thanks to Dr. Gastonguay for teaching
me this trick):
http://www.cognigencorp.com/nonmem/nm/99jan072006.html
Thank-you,
Mahesh
Quoted reply history
-----Original Message-----
From: [email protected]
[mailto:[email protected]]on Behalf Of Bachman, William
Sent: Thursday, April 23, 2009 12:05 PM
To: Leonid Gibiansky; Elassaiss - Schaap, J. (Jeroen)
Cc: [email protected]; TKT (Thomas Klitgaard)
Subject: RE: [NMusers] Resetting af single compartment
I have not tried it either, but, I think this would not reset the amounts in
these compartments. I believe it would retain the value when turned off until
turned back on.
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Leonid Gibiansky
Sent: Thursday, April 23, 2009 11:40 AM
To: Elassaiss - Schaap, J. (Jeroen)
Cc: [email protected]; TKT (Thomas Klitgaard)
Subject: Re: [NMusers] Resetting af single compartment
From the NM help for CMT data item:
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
So my guess is that
EVID CMT
2 -3
2 3
Should reset this particular compartment 3 (although I never tried it)
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Elassaiss - Schaap, J. (Jeroen) wrote:
>
> Thomas,
>
> Two solutions (their smart scale is up to you to judge ;-):
>
> 1 - rewrite the model so you don't need the changepoint (best approach IMHO)
>
> 2 - I guess you could switch the model to a different differential
> equation instead
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
>
>
> ------------------------------------------------------------------------
> *From:* [email protected]
> [mailto:[email protected]] *On Behalf Of *TKT (Thomas Klitgaard)
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* [email protected]
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, without
> resetting the whole system for the
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
> Thomas
>
>
> ____________________
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> *Thomas Klitgaard
> *Principal Scientist
> Biomodelling
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