request for assistance

Dear collegues, Can anyone out there provide me with a data set/control stream that generates the  error: 0PRED EXIT CODE = 1 0INDIVIDUAL NO. 1 ID= 1.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 4 THETA 1.14E+00 -5.36E+00 -1.42E+01 -4.18E+00  9.00E+00 4.21E-01 -6.76E-01 5.63E-01 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.               NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR       TO DIFFERENTIAL EQUATIONS, ; 7, MAY BE TOO LARGE Here is the hard part, it generates after very little run time - ideally in 10 minutes or less. I have any number that throw this at 4 or 6 (or 24) hours, but that makes debugging it hard.thanks Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 (image/png attachment: left.letterhead)

Mark, I have seen this one often enough, but I never tend to save those results like they are the ones I am proud of ;-). I would look into initial values, some bugs in the control stream or model overparameterization. Anyway, a search in a directory tree ended up with one example that provided this statement in just 1 second. A problem is that the dataset is proprietary. So here goes a description: -the parent run crashed with a rounding error (1.0 sigdigs) -I tried 4 variations on the parent model: 1) simplified the $error structure. Crashed with a floating point 2) increased tol to 7 (now I wonder why I did not start with tol=7 in the first place). Crashed with rounding (0.3 sigdigs) but at a higher ofv 3) switch to advan9 and decrease in tol: crashed with lsodi1 (ERROR IN LSODI1: CODE 205) of ID12 4) switch to advan8 and decrease in tol: crashed with the one you mentioned, for ID7. See below -I thereafter fixed the error component I removed in 1) which resulted in a lower ofv. - Further down the line, I ended up in estimation of this parameter again. Hope this helps, Jeroen crash message: MONITORING OF SEARCH: 0PRED EXIT CODE = 1 0INDIVIDUAL NO. 7 ID=0.70000000E+01 (WITHIN-INDIVIDUAL) DATA REC NO. 5 THETA -5.70E+00 -3.60E+00 -3.60E+00 -3.70E+00 0.00E+00 2.40E-01 4.60E+00 7.60E+00 -4.90E+00 -5.20E+00 4.10E+00 3.00E+00 8.00E-01 -2.00E-01 1.00E+00 3.60E-01 2.50E-01 OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE. NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR TO DIFFERENTIAL EQUATIONS, 5, MAY BE TOO LARGE. 0PROGRAM TERMINATED BY OBJ MESSAGE ISSUED FROM ESTIMATION STEP AT INITIAL OBJ. FUNCTION EVALUATION 1THERE ARE ERROR MESSAGES IN FILE PRDERR Jeroen Elassaiss-Schaap, PhD Modeling & Simulation Expert Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3) Early Clinical Research and Experimental Medicine Schering-Plough Research Institute T: +31 41266 9320 _____

Mark, I have seen this one often enough, but I never tend to save those results like they are the ones I am proud of ;-). I would look into initial values, some bugs in the control stream or model overparameterization. Anyway, a search in a directory tree ended up with one example that provided this statement in just 1 second. A problem is that the dataset is proprietary. So here goes a description: -the parent run crashed with a rounding error (1.0 sigdigs) -I tried 4 variations on the parent model: 1) simplified the $error structure. Crashed with a floating point 2) increased tol to 7 (now I wonder why I did not start with tol=7 in the first place). Crashed with rounding (0.3 sigdigs) but at a higher ofv 3) switch to advan9 and decrease in tol: crashed with lsodi1 (ERROR IN LSODI1: CODE 205) of ID12 4) switch to advan8 and decrease in tol: crashed with the one you mentioned, for ID7. See below -I thereafter fixed the error component I removed in 1) which resulted in a lower ofv. - Further down the line, I ended up in estimation of this parameter again. Hope this helps, Jeroen crash message: MONITORING OF SEARCH: 0PRED EXIT CODE = 1 0INDIVIDUAL NO. 7 ID=0.70000000E+01 (WITHIN-INDIVIDUAL) DATA REC NO. 5 THETA= -5.70E+00 -3.60E+00 -3.60E+00 -3.70E+00 0.00E+00 2.40E-01 4.60E+00 7.60E+00 -4.90E+00 -5.20E+00 4.10E+00 3.00E+00 8.00E-01 -2.00E-01 1.00E+00 3.60E-01 2.50E-01 OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE. NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR TO DIFFERENTIAL EQUATIONS, 5, MAY BE TOO LARGE. 0PROGRAM TERMINATED BY OBJ MESSAGE ISSUED FROM ESTIMATION STEP AT INITIAL OBJ. FUNCTION EVALUATION 1THERE ARE ERROR MESSAGES IN FILE PRDERR Jeroen Elassaiss-Schaap, PhD Modeling & Simulation Expert Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3) Early Clinical Research and Experimental Medicine Schering-Plough Research Institute T: +31 41266 9320 _____