PSN vsWings

I have a data set for which I have experienced the following: 1. A Nonmem data set was prepared from SAS/R from an *.xpt file; however, when I tried to run under PSN it returned that it couldn't find the data set. 2. Using a data set that I had previously prepared with SAS and run under PSN (i.e., not from an *.xpt file), I manually added additional subjects with the same sampling scheme and the data set ran under PSN. However when I looked at the outputted fit file only the original subjects had been read in and parameters estimated for them by PSN; 3. When I run estimation with the same data set under Wings it runs okay. Has anyone had a similar experience with data from an *.xpt file and if so how can it be addressed?

Hi Andre, I’m not totally clear what the issue is, but I can help eliminate some of the questions: The original source of the data before generating the NONMEM-ready dataset is not important. The formatting of the NONMEM-ready dataset is vitally important. My guess is that your dataset includes extraneous quotation marks as created by the R command write.csv() (note the dot in the function name). I would guess that if you use write_csv() from the readr library (note the underscore in the function name), it will work because write_csv() does not add extraneous quotation marks. For not being able to find the data, I don’t know how Wings differs from PsN there, but I’d check that the data file path is correct relative to the NONMEM control stream. And, I would run PsN from the same directory as the control stream. Thanks, Bill