From: j.dejongh@lapp.nl
Date: Mon, 21 Aug 2000 13:41:31 +0200
Subject: problem with increasing the number of eta's by changing LVR
Dear NONMEM users,
I encountered a problem when trying to increase the maximum number of eta's for a simulation only model (it has 34 eta's and 1 sigma):
1. I increased the LVR parameter to 50 in NSIZES, LSIZES, PSIZES & TSIZES
2. I decreased the LTH parameter to 20, so that LPAR remained 70
3. I set MTHVR to 50
4. I rebuilt the files succesfully, but still got the error message:
"THE CHARACTERS IN ERROR ARE: 31 454 NO. OF ETAS EXCEEDS CONSTANT "LVR" IN TSIZES", when compiling my model.
Studying the installtion guide has not given me any clues. Any help on this issue is appreciated.
Thanks in advance
Joost DeJongh,
The Netherlands
Dr. Joost DeJongh
Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants
Archimedesweg 31
2333 CM Leiden
The Netherlands
Phone: + 71 524 3000
Phone: + 71 524 3002 (direct line)
fax: + 71 524 3001
problem with increasing the number of eta's by changing LVR
From: j.dejong@CHEM.leidenuniv.nl
Date: Tue, 22 Aug 2000 17:00:28 +0200
Subject: RE: (now solved) Increasing number of theta's and eta's
Dear Dr. Bachman,
Your help was very effective. Deleting the content of all subdirectoreries within the NMV directory was indeed the solution to my problem. After this, I managed to re-install and -compile NM succesfully.
Thank you very much.
Kind regards,
Joost DeJongh
On 21 Aug 00, at 9:51, Bachman, William wrote:
> Step 2 should also read as changed below!!!:
>
> del pr
>
> nmconsult@globomax.com
> GloboMax LLC
> 7250 Parkway Drive, Suite 430
> Hanover, MD 21076
> Telephone: (410) 782-2205
> FAX: (410) 712-0737
>
>
> > -----Original Message-----
> > From: Bachman, William
> > Sent: Monday, August 21, 2000 9:46 AM
> > To: 'j.dejongh@lapp.nl'
> > Cc: nmconsult
> > Subject: Increasing the number of theta's and eta's in NONMEM V
> > [GM000086]
> >
> > Dear Dr. DeJongh
> >
> > Your problem does not appear to be the typical problem associated
> > with exceeding the number of eta's, but, I thought I would forward
> > to you our instructions for increasing the number of thetas and etas
> > so that you can check that your procedure was similar to ours. Hope
> > this helps.
> >
> > nmconsult@globomax.com
> > GloboMax LLC
> > 7250 Parkway Drive, Suite 430
> > Hanover, MD 21076
> > Telephone: (410) 782-2205
> > FAX: (410) 712-0737
> >
> > ====================================================================
> > ====== =====
> >
> > INSTRUCTIONS FOR CHANGING THE LIMIT ON THE NUMBER OF THETAS AND
> > ETAS:
> >
> > NONMEM, PREDPP and NMTRAN need to be recompiled for changes to
> > NSIZES, TSIZES and LSIZES files to take affect.
> >
> > In this example, the maximum number of thetas (LTH) is increased
> > from 40 to 80 and the maximum number of etas (LVR) is changed from
> > 30 to 60.
> >
> > If NONMEM V was installed using the SETUP.BAT installation utility,
> > here is an easy way to make this change.
> >
> > In the following, it is assumed that the NONMEM V directory is
> > c:\nmv. If not, use the appropriate drive and directory.
> >
> > The steps are:
> > 1. Change to c:\nmv and make the changes to NSIZES, TSIZES, PSIZES,
> > and LSIZES
> >
> > To increase the number of allowable THETAS OMEGAS AND SIGMAS, modify
> > the global settings in TSIZES, NSIZES, PSIZES, LSIZES:
> >
> > LTH=80
> > LVR=60
> >
> > and also in NSIZES:
> >
> > MTHVR=80
> >
> > and increase LWS1= to value that is > (LTH+LVR)*(4*LTH+4*LVR+2)+1
> > which, in this case is > 78681. So you might set
> >
> > LWS1=79000
> >
> >
> > 2. Delete all files from the following directories:
> > del nm
> > del tr
> > del tl
> > del pr
> > del util
> >
> > 3. Determine the setup commands used previously to install NONMEM:
> > type setup.txt
> >
> > 4. Use SETUP.BAT to recompile all routines. (Use here the same
> > arguments that were used originally, if any.) SETUP.BAT will
> > automatically skip all other steps.
> > setup a c nmv df y
> >
> > In the above, it is assumed that SETUP.BAT remains in the NONMEM V
> > directory where it was copied during installation. If not, it can
> > be run from diskette as it was originally:
> > a:\SETUP
> > ====================================================================