Position: Post-doctoral Associate in Pharmacometrics and Systems Pharmacology
Department: Center for Pharmacometrics and Systems Pharmacology (CPSP), College
of Pharmacy, University of Florida
Faculty member: Dr. Sihem Bihorel. MS., PharmD., PhD
Position description: The CPSP in Lake Nona (Orlando, FL) in collaboration with
Bohringer Ingelheim is offering a two years, full time, post-doctoral associate
position in clinical pharmacokinetics-pharmacodynamics (PK/PD) and quantitative
systems pharmacology (QSP).
This position starts immediately and focuses on the application of QSP with
population PK/PD analysis and disease progression modeling in the area of
exposure-response of novel oral anticoagulants and their management using
combination therapies with reversal agents.
During the two years training at the CPSP, the post-doctoral candidate will
have the opportunity to gain a breadth of experience in:
* Population PK/PD and complex mechanism-based modeling of biotechnology
and small molecule drugs
* Development and qualification of QSP models and bridging these models
to clinical PK/PD and disease progression models
* Development and evaluation of the advanced numerical and computational
methods for population PK/PD data analysis
* Development and qualification of novel PK/PD visualization tools for
QSP and population PK/PD analyses.
* Disease progression and risk prediction modeling for patients with
bleeding disorders
* Report within the project in terms of written reports/publications and
oral presentations
Qualifications required: An ideal candidate will have a doctoral degree (PhD)
in Pharmaceutics, Pharmacometrics (PK/PD), Systems biology/pharmacology,
Statistics, applied Mathematics with an interest in pursuing a career in
clinical pharmacology and/or pharmacometrics & QSP. The candidate must have
experience with population PK/PD modeling software applications such as NONMEM
and or Monolix, have programming experience with R and or SAS, is acquainted
with MATLAB, have experience in analyzing data describing biologic or PK/PD
systems using a non-linear mixed effects modeling approaches, an understanding
of PK and PD theory, particularly as pertaining to biologic agents will be
advantageous.
How to apply: Please send CV, a brief letter of interest, and the names and
email addresses of three referees to Dr. Sihem Bihorel, MS., PharmD., PhD via
e-mail to [email protected]<mailto:[email protected]>.
CPSP Overview: The CPSP ( http://cpsp.pharmacy.ufl.edu/) is located in the
University of Florida Academic & Research Center at the Lake Nona Medical City
about 5 miles southeast of the Orlando International Airport. The CPSP provides
an academic home to a multidisciplinary and integrative, quantitative clinical
pharmacology program in drug development and regulatory science. Lake Nona
Medical City ( http://www.lakenona.com/medical-city/) is a landmark for Orlando
and a premier location for medical care, research and education. It is anchored
by University of Central Florida Medical School, the Sanford-Burnham Medical
Research Institute, the newest VA Medical Center in the country, the Nemours
Children's Hospital, and the University of Florida Academic and Research Center.