**We apologize if you receive multiple copies of this announcement**
Dear all,
We are pleased to announce the availability of the software PFIM Interface 2.1,
an extension of PFIM with a graphical user interface. It is dedicated to
evaluation and optimisation of population designs for single response models in
the context of population analyses using the R software. No skill in R is
required to use this new version, available for both Windows and Linux
environment.
Compared to PFIM 1.2 and PFIMOPT 1.0, the previous versions of PFIM, options
have been added for model specification and for optimisation. The model can be
written using an analytical form or using a differential equation system.
Moreover, with this new version, a library of pharmacokinetic models is
available. Concerning optimisation step, the Federov-Wynn algorithm has been
added as an alternative to the Simplex algorithm. This algorithm allows design
optimisation with fixed sampling times specified by users. This can be a great
advantage with respects to medical constraints.
PFIM Interface 2.1 can be downloaded on the new PFIM website:
www.pfim.biostat.fr
PFIM Interface 2.1 is registered at the APP (Agency for the Protection of
Programs) and is distributed under the terms of the GNU GENERAL PUBLIC LICENSE
(GNU GPL) Version 2, June 1991.
Best regards,
Caroline Bazzoli and Sylvie Retout
Copyright © PFIM Interface 2.1 - Sylvie Retout, Hervé Le Nagard, Emmanuelle
Comets, Caroline Bazzoli, France Mentré - Université Paris Diderot - INSERM
Caroline BAZZOLI
INSERM U738
Faculté de Médecine Xavier Bichat
16 rue Henri Huchard
Tel : 01 44 85 62 78
75018 Paris-France
[EMAIL PROTECTED]