Associate Scientific Director, PK/PD Modeling-9659140429
Description
Janssen Research & Development, L.L.C., a Johnson & Johnson company, is
recruiting an Associate Scientific Director to be located in Spring House, PA.
Janssen Research & Development, L.L.C. develops treatments that improve the
health and lifestyles of people worldwide. Research and development areas
encompass novel targets in neurologic disorders, gastroenterology, oncology,
infectious disease, diabetes, hematology, metabolic disorders, immunologic
disorders, and reproductive medicine.
Janssen Pharmaceuticals, Inc., a pharmaceutical company of Johnson & Johnson,
provides medicines for an array of health concerns in several therapeutic
areas, including: attention deficit hyperactivity disorder (ADHD),
cardiovascular disease, general medicine (acid reflux disease, infectious
diseases), mental health (bipolar I disorder, schizophrenia), neurologics
(Alzheimer's disease, epilepsy, migraine prevention and treatment), pain
management, and women's health. Our ultimate goal is to help people live
healthy lives. We have produced and marketed many first-in-class prescription
medications and are poised to serve the broad needs of the healthcare market -
from patients to practitioners, from clinics to hospitals. For more about
Janssen Pharmaceuticals, Inc., one of the Pharmaceutical Companies of Johnson &
Johnson, visit www.janssenpharmaceuticalsinc.com
The Associate Scientific Director will conduct advanced PK/PD modeling research
with emphasis on disease progression modeling and implementation of
mechanism-based approaches. Will support product development as Model Based
Drug Development (MBDD) Leader by defining the
dose-concentration-pharmacological effect relationships of drugs using modeling
and simulation methodologies from data acquired at various stages of drug
research and development. Perform basic and clinical disease research, with a
focus on Oncology, Immunology and/or Infectious Diseases compounds. Perform
population PK and PK/PD analysis for regulatory submissions. The successful
candidate uses state-of-the-art computer modeling and simulation techniques to
formulate various clinical trial design scenarios and outcome analyses. Will
have full technical responsibility for interpreting, organizing, executing, and
coordinating assignments. Conceptualize plan, develop and execute R&D projects
that have a major impact on key development programs, and acts as the MBDD
representative on Clinical and/or Compound Development Teams. Actively maintain
relationships and collaborate with colleagues within or outside the MBDD
organization and J&J at large. Part of the Associate Scientific Director's time
will need to be devoted at establishing and maintaining external collaborations
with Academic groups active in Oncology, Immunology and/or Infectious Diseases
worldwide. Will be responsible for acting independently on scientific and
technical matters pertaining to his/her field, to drive advancing the science
in the field, to identify research opportunities and to coordinate them. The
successful candidate will serve as senior technical expert for the organization
in the application of advanced PK/PD and disease modeling principles, as well
as in mechanism-based concepts and processes.
Thriving on a diverse company culture, celebrating the uniqueness of our
employees and committed to inclusion. Proud to be an equal opportunity employer.
Qualifications
A minimum of a Master's degree in Pharmaceutical Sciences, Clinical
Pharmacology, Chemical/Biomedical Engineering or related discipline with a
minimum of 10 years of pharmaceutical development experience in various aspects
of modeling and simulation is required OR a PhD in Pharmaceutical Sciences,
Clinical Pharmacology, Chemical/Biomedical Engineering or related discipline
with a minimum of 6 years of pharmaceutical development experience in various
aspects of modeling and simulation is preferred.
Hands-on experiences with population approach in describing PK/PD systems with
various types of clinical pharmacology data is required.
Demonstrated experience identifying research projects and successfully managing
them in collaboration with internal or external teams is required.
In-depth knowledge of preclinical or clinical pharmacokinetics, drug
metabolism, PK/PD modeling principles and statistics is required.
Experience with NONMEM, R and/or other modeling and simulation software is
required.
Thorough knowledge of planning, conducting, evaluating and reporting PK/PD
studies in R&D is required
The ability to perform basic and clinical disease research, with a focus on
Oncology, Immunology and/or Infectious Diseases compounds is preferred.
Excellent communication and interpersonal skills is required.
Experience with biologics drug development is preferred.
Experience working with cross functional teams is preferred.
Johnson & Johnson companies are equal opportunity employers.
To apply, please visit http://careers.jnj.com/full-time-opportunities and enter
job number: 9659140429
Chuanpu
~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*
Chuanpu Hu, Ph.D.
Scientific Director
Model Based Drug Development
Janssen Pharmaceutical Companies of Johnson & Johnson
1400 McKean Road, PO Box 776, Spring House, PA 19477
Office Phone: 215-793-7288
Fax: 215-986-1013
E-mail: [email protected]<mailto:[email protected]>
~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*