Scientific Director - PK/PD Modeling Job at Johnson & Johnson (8896141109)
Date: Dec 03, 2014
Location: Spring House, PA, US
Description
Janssen Research & Development, L.L.C., a Johnson & Johnson company, is
recruiting a Scientific Director of PK/PD Modeling to be located in Spring
House, PA. Additional positions are also available commensurate to experience.
Janssen Research & Development, L.L.C. develops treatments that improve the
health and lifestyles of people worldwide. Research and development areas
encompass novel targets in neurologic disorders, gastroenterology, oncology,
infectious disease, diabetes, hematology, metabolic disorders, immunologic
disorders, and reproductive medicine.
Janssen Pharmaceuticals, Inc., a pharmaceutical company of Johnson & Johnson,
provides medicines for an array of health concerns in several therapeutic
areas, including: attention deficit hyperactivity disorder (ADHD),
cardiovascular disease, general medicine (acid reflux disease, infectious
diseases), mental health (bipolar I disorder, schizophrenia), neurologics
(Alzheimer's disease, epilepsy, migraine prevention and treatment), pain
management, and women's health. Our ultimate goal is to help people live
healthy lives. We have produced and marketed many first-in-class prescription
medications and are poised to serve the broad needs of the healthcare market -
from patients to practitioners, from clinics to hospitals. For more about
Janssen Pharmaceuticals, Inc., one of the Pharmaceutical Companies of Johnson &
Johnson, visit http://www.janssenpharmaceuticalsinc.com/
Thriving on a diverse company culture, celebrating the uniqueness of our
employees and committed to inclusion. Proud to be an equal opportunity employer.
The Scientific Director will conduct advanced PK/PD modeling research with
emphasis on disease progression modeling and implementation of mechanism-based
approaches. Will support product development as Model Based Drug Development
(MBDD) Leader by defining the dose-concentration-pharmacological effect
relationships of drugs using modeling and simulation methodologies from data
acquired at various stages of drug research and development. Perform basic and
clinical disease research, with a focus on CNS, Immunology, and/or Oncology
compounds. Perform population PK and PK/PD analysis for regulatory submissions.
The successful candidate uses state-of-the-art computer modeling and simulation
techniques to formulate various clinical trial design scenarios and outcome
analyses. Will have full technical responsibility for interpreting, organizing,
executing, and coordinating assignments. Conceptualize plan, develop and
execute R&D projects that have a major impact on key development programs, and
acts as the MBDD representative on Clinical and/or Compound Development Teams.
Actively maintain relationships and collaborate with colleagues within or
outside the MBDD organization and J&J at large. Part of the Scientific
Director's time will need to be devoted at establishing and maintaining
external collaborations with Academic groups active in CNS, Immunology, and/or
Oncology worldwide. Will be responsible for acting independently on scientific
and technical matters pertaining to his/her field, to drive advancing the
science in the field, to identify research opportunities and to coordinate
them. The successful candidate will serve as senior technical expert for the
organization in the application of advanced PK/PD and disease modeling
principles, as well as in mechanism-based concepts and processes.
Qualifications
A minimum of a Master's degree in Pharmaceutical Sciences, Clinical
Pharmacology, Chemical/Biomedical Engineering or related discipline with a
minimum of 10 years of pharmaceutical development experience in various aspects
of modeling and simulation is required OR a Ph.D. in Pharmaceutical Sciences,
Clinical Pharmacology, Chemical/Biomedical Engineering or related discipline
with a minimum of 8~10 years of pharmaceutical development experience in
various aspects of modeling and simulation is preferred.
Hands-on experiences with population approach in describing PK/PD systems with
various types of clinical pharmacology data is required. Demonstrated
experience identifying research projects and successfully managing them in
collaboration with internal or external teams is required. In-depth knowledge
of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD modeling
principles and statistics is required. Experience with NONMEM, R and/or other
modeling and simulation software is required. Thorough knowledge of planning,
conducting, evaluating and reporting PK/PD studies in R&D is required. The
ability to perform basic and clinical disease research, with a focus on
Oncology, Immunology and/or Infectious Diseases compounds is preferred.
Excellent communication and interpersonal skills is required. Experience with
biologics drug development is preferred. Experience working with cross
functional teams is preferred.
Johnson & Johnson companies are equal opportunity employers.
To apply, please visit http://careers.jnj.com/full-time-opportunities and enter
job number: 8896141109
Honghui Zhou, PhD, FCP
US Head, Pharmacological and Translational Modeling
Model-Based Drug Development
[Janssen_Hor_RGB]
Janssen Research & Development, LLC
Welsh & McKean Roads
P.O. Box 776
Spring House PA 19477
Tel: + 1 215.793.7261 Fax: +1 215.986.1013
[email protected]<mailto:[email protected]>