GlaxoSmithKline (GSK) has a two-year position for a highly motivated
Pharmacometrician to join our global department of Clinical Pharmacology
Modelling & Simulation. This is an excellent opportunity to apply
pharmacometrics to accelerating the delivery of new medicines to patients by
enhancing drug program efficiency and business decision quality.
The main project will be applying Item Response Theory to rating scales in
neurodegenerative diseases. Embedded in an organization where we develop
therapies of various modalities for a broad range of indications at stages from
pre-clinical to post-approval development, you will have tremendous
opportunities for broad exposure to drug discovery and development.
Responsibilities:
* Plan, conduct and report item response modelling, disease progression
modelling, simulation-based trial design and exposure-response analysis to
maximise data use, trial efficiency and analysis power
* Contribute to clinical trial design, and discuss modelling strategy and
outcome to project teams and governance boards
* Promote model-informed drug discovery and development through
internal/external collaboration, journal publication and conference presentation
Requirements:
* Advanced training in pharmacometrics or statistics, and experience in
using modelling/simulation to solve practical problems in industry or academia
* Familiarity with item response theory, longitudinal disease modelling
and model-based meta-analysis; proficiency with software NONMEM, MONOLIX, R and
SAS
* Aptitude for productive collaboration in a multi-discipline team,
effective communication and taking personal accountability for timely result
delivery
Working in a department of diverse expertise and on multi-discipline teams, you
will enjoy a highly supportive environment for innovation, influence and
growth. The ideal primary work location will be in London (UK) or Philadelphia
(USA) area, though there is flexibility for the right candidate. Interested
persons are encouraged to apply online
https://careers.peopleclick.com/careerscp/client_gsk/external1931/gateway.do?functionName=viewFromLink&jobPostId=403072&localeCode=en-us.
Chao Chen
Clinical Pharmacology Modelling & Simulation, GSK R&D
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