Temporary position as Pharmacometrician/Pharmacokineticist within the in-vivo
section, DMPK, at AstraZeneca R&D Södertälje.
The Arena
AstraZeneca is one of the top 10 pharmaceutical companies whose success is
built upon good science and innovation and we have an exciting discovery
portfolio. In Södertälje, the discovery research is focussed on CNS and Pain
Control. At the DMPK department, we are involved in project work from project
generation to CD selection with the screening and characterization of in vitro
and in vivo ADME properties of compounds. The in vivo section supports in vivo
pharmacokinetics and provides pharmacokinetic-pharmacodynamic (PK/PD) analysis
to the projects.
We are now looking for a Pharmacometrician/Pharmacokineticist to join our team
in Södertälje.
The Role
You will participate in the screening process of chemical compounds in drug
discovery with regards to pharmacokinetics and you will be involved in
establishing PKPD (pharmacokinetics-pharmacodynamic) relationships. Planning,
coordination as well as active participation in studies is part of your work,
and you will be responsible for gathering and presenting the study results to
project teams. Furthermore, you will be working with understanding of the
correlation between in-vitro and in-vivo ADME properties and the relationship
between pharmacokinetics and pharmacodynamic responses including biomarkers for
mechanism of action.
Collaboration with other team members and other researchers within and outside
AstraZeneca R&D is key in our drug discovery process, which means that you need
to be able to represent the department on scientific meetings and at project
presentations.
Requirements
* You have a PhD in pharmaceutical sciences.
* You have previous work experience within pharmacokinetics and
understand the physiological mechanisms behind absorption, distribution,
metabolism and excretion.
* Previous experience with PK and PKPD (in pre-clinical phase) as well as
in-vitro and in-vivo ADME assays is needed.
* The applicant should have a good working knowledge in spoken and
written English
* Experience with WinNonLin, Nonmem and Berkeley Madonna
Success factors
* Capability to develop own work tasks
* Good written and oral communication skills
* Result driven
* High degree of flexibility
* Structured way of working
* Works collaboratively
* Problem solving
More Information
Applications should go via www.astrazeneca.com, carreers, sweden, english
vacancies: Pharmacometrician/Pharmacokineticist, temporary-SOD000000IZ
SE-Sodertalje
For more information please contact: Annette Persson (+46 8553 27507) or Janet
Hoogstraate (+46 8553 25810). We would like your application no later than
March 29, 2009.