Every colleague, every country, every day, makes an impact.
Have a positive effect.
Our Pharmacometricians have key roles to play in influencing the discovery and
development of drugs. It's fascinating, vital work and you could be part of
it. We have made the strategic decision to significantly enhance our workforce
in this discipline because of its critical importance to our organization.
Therefore we have several new positions for talented individuals at a number of
US sites.
Pharmacometricians (Disease Area Point of Contact) at Groton, CT
In this key role as a member of our Global Pharmacometrics group you will be
responsible for providing expert study/program design, data analytical and
interpretation inputs to our various Research and Business Unit (RU/BU)
organizations. The successful candidates will work as partners of disease area
aligned multi-disciplinary teams in providing model based drug development
expertise and leadership to a variety of drug discovery and development
programs through to loss of patent exclusivity. Of key importance will be the
formation and maintenance of effective collaborations with amongst others,
statistical, clinical and clinical pharmacology members of these teams.
Pharmacometricians provide strategic input into pre-clinical discovery,
development and post-approval plans quantifying the risk associated with
particular study designs or program strategies and communicating/dissemination
of the results. They are responsible for the use of a variety of innovative
quantitative methods to integrate knowledge of pharmacokinetics, a variety of
response variables (including pharmacodynamic, clinical outcome and undesirable
effects), patient characteristics and disease mechanism/states, statistics,
study/experimental design, clinical trial simulations, meta-analytical evidence
synthesis and quantitative techniques to facilitate quantitative decision
making thereby increasing RU/BU efficiency.
In addition to the disease specific activities the successful candidates will
forge collaborative relationships with Pharmacometric colleagues within the
global Pharmacometrics community (currently based in USA, UK, China and Japan),
other subject matter specialists and groups external to the organization
(leading academics, external service providers etc.). The successful candidates
will work with colleagues to ensure Pfizer's position as a leader in the use of
quantitative approaches supporting drug development strategies and worldwide
registration of new medicines.
Pharmacometricians (Individual Contributor) at Groton, CT and Cambridge, MA
In this key role you will serve as the Pharmacometrics representative on
multidisciplinary discovery and/or development teams and provide Pharmacometric
expertise and leadership to a project. In the research units the position can
entail partnering with research based colleagues to select and validate
clinical targets in order to design efficient and informative proof of
mechanism and proof of concept studies. In the business units, the position
can entail partnering with development colleagues to integrate prior knowledge
in order to develop innovative clinical study designs for Phase II-IV clinical
trials by applying the principles of model based drug development.
Pharmacometricians work closely with Clinical Pharmacology Leads, Clinicians
and Statisticians to create clinical development plans that include assessments
of a drug's efficacy, safety, commercial viability and fulfilment of
registration requirements.
In order to achieve these aims, candidates are responsible for the use of
innovative analytical methods to integrate knowledge of pharmacokinetics,
pharmacodynamics, patient characteristics and disease states to optimize doses,
dosage regimens and study designs throughout clinical drug development.
Pharmacometricians routinely interact with internal governance bodies,
regulatory agencies and external opinions leaders. They are expected to
influence the external environment by advancing their discipline and through
external presentations and publications.
The ideal candidates will have a doctorate degree with demonstrated expertise
in Clinical Pharmacology and/or Pharmacometrics and strong quantitative skills
(e.g. experience in mechanistic modeling/systems pharmacology, quantitative
translational scaling, literature meta-analyses, population modeling, and
clinical trial simulations). We encourage applicants from different disciplines
including biostatistics, medicine, engineering, etc. Candidates with
significant experience are sought as well as recent graduates. In addition to
professional challenge, we offer a culture that supports and encourages ideas,
and recognizes individual contribution. Moreover, the salary and extensive
benefits are everything you'd expect from a world leading company
To apply please visit the careers pages on
http://www.pfizer.com and enter the following job opening
numbers:
For Pharmacometrics (Disease Area Point of Contact), job opening number: 961330
For Pharmacometrics (Individual Contributor), job opening number: 961325
Regards,
Peter
Peter A. Milligan
Head of Pharmacometrics
Global Clinical Pharmacology
+44 (0)1304 648954 (telephone)
+44 (0)1304 652590 (fax)
+44 (0)7966 130579 (mobile)
[email protected]<mailto:[email protected]>
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