Hi
I was wondering if anyone has experience modeling the effect of three separate
drugs on the same biomarker. In my area of research in organ transplantation,
patients often take three immunosuppressive agents concomitantly, all of which
will contribute toward a PD marker (i.e. reduction of intracellularly
expressed IL-2 in mitogen stimulated lymphocytes). Most published work on
drug combinations, however, deal with agonistic or antagonistic activity of
two drugs as summarized by Jonker et al, 2005.
All suggestions or advice are greatly appreciated.
Fatemeh
Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA
Phone/Fax: (401) 874 9205/(401) 874 2181
Email: fatemeh
Laboratory Website: http://www.uri.edu/pharmacy/faculty/aps/akhlaghi
PD of drugs in combination therapy
Hi
I was wondering if anyone has experience modeling the effect of three separate
drugs on the same biomarker. In my area of research in organ transplantation,
patients often take three immunosuppressive agents concomitantly, all of which
will contribute toward a PD marker (i.e. reduction of intracellularly
expressed IL-2 in mitogen stimulated lymphocytes). Most published work on
drug combinations, however, deal with agonistic or antagonistic activity of
two drugs as summarized by Jonker et al, 2005.
All suggestions or advice are greatly appreciated.
Fatemeh
Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA
Phone/Fax: (401) 874 9205/(401) 874 2181
Email: [email protected]
Laboratory Website: http://www.uri.edu/pharmacy/faculty/aps/akhlaghi
Dear Fatemeh,
Some work regarding three drug combinations has been published regarding
anesthetic combinations:
Flexible interaction model for complex interactions of multiple anesthetics.
Fidler M, Kern SE.
Anesthesiology. 2006 Aug;105(2):286-96.
Response surface model for anesthetic drug interactions.
Minto CF, Schnider TW, Short TG, Gregg KM, Gentilini A, Shafer SL.
Anesthesiology. 2000 Jun;92(6):1603-16.
These models can handle up to three drugs ( appendix of the before mentioned
manuscripts).
Hope this helps,
Bests,
Samer
Quoted reply history
-----Original Message-----
From: [email protected] on behalf of Fatemeh Akhlaghi, PhD
Sent: Mon 1/26/2009 21:50
To: [email protected]
Subject: [NMusers] PD of drugs in combination therapy
Hi
I was wondering if anyone has experience modeling the effect of three separate
drugs on the same biomarker. In my area of research in organ transplantation,
patients often take three immunosuppressive agents concomitantly, all of which
will contribute toward a PD marker (i.e. reduction of intracellularly
expressed IL-2 in mitogen stimulated lymphocytes). Most published work on
drug combinations, however, deal with agonistic or antagonistic activity of
two drugs as summarized by Jonker et al, 2005.
All suggestions or advice are greatly appreciated.
Fatemeh
Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA
Phone/Fax: (401) 874 9205/(401) 874 2181
Email: [email protected]
Laboratory Website: http://www.uri.edu/pharmacy/faculty/aps/akhlaghi