Parameter Shrinkage

Greetings All! I am revising a pop PK paper and one of the reviewers would like to see parameter shrinkage reported. Does anyone know how to compute this? And, what is considered "low" verses "high" shrinkage? Thanks so much in advance for any help you can offer! Susan Susan Hudachek, M.S., Ph.D. Animal Cancer Center Veterinary Teaching Hospital Colorado State University 300 West Drake Road Fort Collins, CO 80523-1620 PHONE: (970) 219-7599 FAX: (970) 297-1254 EMAIL: [email protected]<mailto:[email protected]>

Maybe, this presentation could provide you some information. Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics and Estimation: Problems and Solutions Radojka M. Savic and Mats O. Karlsson http://www.page-meeting.org/default.asp?abstract=1087 "Hudachek,Susan" <[email protected]> Enviado por: [email protected] 06/07/2009 21:46 Para "[email protected]" <[email protected]> cc Asunto [NMusers] Parameter Shrinkage Greetings All! I am revising a pop PK paper and one of the reviewers would like to see parameter shrinkage reported. Does anyone know how to compute this? And, what is considered "low" verses "high" shrinkage? Thanks so much in advance for any help you can offer! Susan Susan Hudachek, M.S., Ph.D. Animal Cancer Center Veterinary Teaching Hospital Colorado State University 300 West Drake Road Fort Collins, CO 80523-1620 PHONE: (970) 219-7599 FAX: (970) 297-1254 EMAIL: [email protected]

Susan, The one I really liked was: M O Karlsson and R M Savic, Diagnosing Model Diagnostics, Clinical Pharmacology & Therapeutics (2007) 82, 17-20. doi:10.1038/sj.clpt.6100241 Douglas Eleveld ________________________________