This is an exciting time to be at Pfizer.
Our Pharmacometricians have an important role in influencing the discovery and
development of drugs. It's fascinating, vital work and you could be part of it.
Pharmacometricians at US locations
In this key role as a member of our Global Pharmacometrics group within the
Clinical Pharmacology Department, you will be responsible for providing expert
study/program design, data analytical and interpretation inputs to our various
Research, Development and Business Unit organizations. The successful
candidates will work as partners of disease area aligned multi-disciplinary
teams in providing model informed drug discovery and development expertise and
leadership to a variety of through to loss of patent exclusivity. Of key
importance will be the formation and maintenance of effective collaborations
with amongst others, statistical, clinical and clinical pharmacology members of
these teams.
Pharmacometricians provide strategic input into pre-clinical discovery,
development and post-approval plans quantifying the risk associated with
particular study designs or program strategies and communicating/dissemination
of the results. They are responsible for the use of a variety of innovative
quantitative methods to integrate knowledge of pharmacokinetics, a variety of
response variables (including pharmacodynamic, clinical outcome and undesirable
effects), patient characteristics and disease mechanism/states, statistics,
study/experimental design, clinical trial simulations, meta-analytical evidence
synthesis and quantitative techniques to facilitate quantitative decision
making thereby increasing drug research and development efficiency.
In addition to the disease specific project activities the successful
candidates will forge collaborative relationships with Pharmacometric
colleagues within the Global Pharmacometrics community (currently based in USA,
UK, China and Japan), other subject matter specialists and groups external to
the organization (leading academics, external service providers etc.). The
successful candidates will work with colleagues to ensure Pfizer's position as
a leader in the use of quantitative approaches supporting drug research and
development strategies and worldwide registration of new medicines.
Pharmacometricians routinely interact with internal governance bodies,
regulatory agencies and external opinions leaders. They are expected to
influence the external environment by advancing their discipline and through
external presentations and publications.
The ideal candidates will have a doctorate degree with demonstrated expertise
in Pharmacometrics and strong quantitative skills (e.g. experience in
mechanistic modelling/systems pharmacology, quantitative translational scaling,
literature meta-analyses, population PK and PK-PD modelling, and clinical trial
simulations). We encourage applicants from different disciplines including
pharmaceutical sciences, biostatistics, medicine, engineering, etc. Candidates
with significant experience are sought as well as recent graduates. In addition
to professional challenge, we offer a culture that supports and encourages
ideas, and recognizes individual contribution. Moreover, the salary and
extensive benefits are everything you'd expect from a world leading company
To apply please visit the careers pages on
http://www.pfizercareers.com and enter the relevant job
opening number:
If you are early in your career please consider a Pharmacometrics Manager
position, and look for job opening number: 1610568 and 1614913. If you have an
established track record of drug research and development impact please
consider a Pharmacometrics Director position, and look for job opening number:
1045468.
Timothy Nicholas, PhD
Pharmacometrician-POC
Global Clinical Pharmacology
[email protected]<mailto:[email protected]>