APPLYING PREDICTIVE SCIENCE AT ASTRAZENECA: OPPORTUNITIES IN MODELLING &
SIMULATION JOBS
The new R&D strategy at AstraZeneca includes a substantial increase in
investment in Predictive Sciences - so we can tackle illness and disease with
even more effective drugs. So from cancer to diabetes and beyond, we will
apply the model-based approach to the whole drug development process. To
realise this, we are making significant investments in people. If you're
already in a modelling and simulation role, or have a background in
bio-mathematical modelling, quantitative systems biology, applied mathematics,
engineering, pharmacokinetics or statistics, then you may have the skills to
make a big contribution to the development of important new medicines. Within
the Clinical Science Department we have currently vacancies for the following
three roles: Therapetic Area Pharmacometrics Expert (ref SWE000000NR, location
Gothenburg/Mölndal, Sweden or Wilmington, US), Section Director Pharmacometrics
(ref SWE000000NS , location Gothenburg/Mölndal, Sweden or Wilmington, US) and
Pharmacometrician/Senior Pharmacometrician (ref SWE000000NS, location: all
sites). The role descriptions together with contact details are given below and
at http://jobs.astrazeneca.com/
Welcome to apply for any of the positions at
http://www.astrazeneca.se/Career/Vacancies?itemId=3184958&nav=yes
http://www.astrazeneca.se/Career/Vacancies?itemId=3184958&nav=yes ! Include
job number as search string.
Closing date is July 10, 2011.
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THERAPEUTIC AREA PHARMACOMETRICS EXPERT, CV/GI or R&I
Job number: SWE000000NR
Location: Mölndal/Gothenburg, Sweden or Wilmington, US
The Therapeutic Area Pharmacometrics Expert position is a strategic and
scientific job within Clinical Pharmacology Science, accountable for the
modelling work being performed within a specific Therapeutic Area (TA). The
current openings are within Cardiovascular/Gastrointestinal (CV/GI) and
Respiratory/Inflammation (R&I) TAs. This person will also apply disease
modelling to clinical program design with a clear sight of models available
internally and externally. The incumbent will provide the strategic direction
to enable the Director of Pharmacometrics to deploy PM resources to the
projects where modelling will have the greatest impact. As a member of the
Senior Leadership of Clinical Pharmacology Science, he/she will contribute to
the strategic direction and business effectiveness of the department.
He/she may be responsible for one or for multiple global drug projects within
the same indication / therapeutic area. He/she leads large and/or complex
projects, interacts with regulatory authorities and key opinion leaders,
provides coaching and mentoring to other pharmacometricians providing support
to projects in the TA, and is accountable for the pharmacometric soundness of
the modelling and simulation efforts for the assigned projects. He/she is
expected to complete these tasks with very minimal supervision, appropriately
and pro-actively seeking line management intervention where needed to ensure
successful outcome, e.g. with respect to project resource requirements or key
strategic functional issues.
Minimum experience
For the Therapeutic Area Pharmacometric Expert (TAPE) role, the applicant has
preferably a doctorate degree with demonstrated expertise in pharmacometrics,
with substantial knowledge about contemporary software and tools within the
field of M&S and strong quantitative skills (e.g. experience in mechanistic
modelling/systems pharmacology, quantitative translational scaling, literature
meta-analyses, population modelling). The TAPE's experience may have been
gained in a variety of disciplines including pharmacology, pharmaceutical
sciences, biostatistics, medicine, physiology, or engineering. Significant
experience should have been gained by working in drug development in the
pharmaceutical industry.
More information
For more information about the positions please contact Marie Sandström,
Director Clinical Pharmacometrics +46 8 553 27835
([email protected]).
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SECTION DIRECTOR CLINICAL PHARMACOMETRICS
Job number: SWE000000NS
Location: Gothenburg/Mölndal, Sweden and Wilmington, US
This is a role within our Clinical Pharmacology Science group which is involved
in candidate drug (CD) selection and in all clinical phases of the product
development including registration and commercialization.
The Section Director Clinical Pharmacometrics combines line management with the
scientific role of Sr Clinical Pharmacometrician with responsibilities for
development of pharmacostatistical models including disease models, exposure
response models, biomarker - efficacy models etc. The Sr Clinical
Pharmacometrician is accountable for developing MBDD plans for assigned
projects.
As a Section Director, he/she will be responsible for all line management
accountabilities for up to 8-12 Pharmacometrician as direct reports and will
work together with Section Director colleagues, the global Director Clinical
Pharmacometrics and Therapeutic Area Pharmacometrics Experts to ensure
recruitment, training, development and deployment of Pharmacometricians, to
optimize project delivery and to support implementation of Model Based Drug
Development within AstraZeneca.
Minimum experience
For the Section Director Clinical Pharmacometrics role, a doctorate degree with
demonstrated expertise in pharmacometrics and strong quantitative skills (e.g.
experience in mechanistic modelling/systems pharmacology, quantitative
translational scaling, literature meta-analyses, population modelling) is
required. The pharmacometrics experience may have been gained in a variety
disciplines including pharmacology, pharmaceutical sciences, biostatistics,
medicine, mathematics, physiology, or engineering. At least 5 years of his/her
experience should have been gained by working in drug development in the
pharmaceutical industry. The applicant should preferably have experience in
line management, training of others and/or scientific supervision.
More information
For more information about the positions please contact Marie Sandström,
Director Clinical Pharmacometrics +46 8 553 27835
([email protected]).
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CLINICAL PHARMACOMETRICIAN/SENIOR CLINICAL PHARMACOMETRICIAN
Job number SWE000000NT
Location: Various
Clinical Pharmacometrician (PM) and Senior Clinical Pharmacometrician (Sr PM)
are scientific roles within our Clinical Science group which is involved in
candidate drug (CD) selection and in all clinical phases of the product
development including registration and commercialization. We are looking for
several individuals to fill the roles in Sweden, UK and the US.
The PM/Sr PM works closely together with other modelling skills (such as
preclinical PKPD scientists, statistical modelers etc ) to develop MBDD plans
for disease area related as well as compound related modelling. The PM/Sr PM
develops pharmacostatistical models including disease models, exposure response
models, biomarker - efficacy models etc. The PM/Sr. PM works as a partner in
multi-disciplinary development teams by providing MBDD expertise. Effective
collaborations with physicians, DMPK PK/PD scientists, statisticians, clinical
pharmacologists and regulatory affairs experts are of key importance.
The Sr PM will, together with statisticians, have the overall accountability
for the MBDD plan. We will also look to these individuals to collaborate
externally by publishing their work, building relationships with academic
institutions and building their expertise by networking with individuals in the
pharmacometrics field. Individuals in the senior role will also be called upon
to coach less senior staff in their modelling work.
Minimum experience
For the Sr. Pharmacometrician role, a doctorate degree with demonstrated
expertise in pharmacometrics and strong quantitative skills (e.g. experience in
mechanistic modelling/systems pharmacology, quantitative translational scaling,
literature meta-analyses, population modelling) is required. For the PM role,
candidates will have a doctorate degree (preferred) but a Master's degree and
other relevant academic training in pharmacometrics and quantitative sciences
is acceptable. The PM´s/Sr. PM's experience may have been gained in a variety
disciplines including pharmacology, pharmaceutical sciences, biostatistics,
medicine, mathematics, physiology, or engineering. At least 5 years of the Sr
PM´s experience should have been gained by working in drug development in the
pharmaceutical industry.
More information
For more information about the positions please contact Marie Sandström,
Director Clinical Pharmacometrics +46 8 553 27835
([email protected]) or for location in Sweden Section Director
Clinical Pharmacometrics Per-Henrik Zingmark +46 8 553 23942
([email protected]), location in UK Section Director Clinical
Pharmacometrics Marc-Antoine Fabre +44 1509 644253
([email protected]) and for location in the US Section
Director Clinical Pharmacometrics Bruce Birmingham +1 302 886 7527
([email protected])
Marie Sandström
On behalf of Clinical Pharmacology Sciences Leadership Team
______________________________________________
Marie Sandström, PhD
Director Clinical Pharmacometrics
AstraZeneca R&D
+46 8 553 27835
+46 708 467727
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