Merck KGaA is seeking one creative, motivated Pharmacometrician to join its
Pharmacometrics team at Darmstadt headquarter (Germany). To apply please visit
https://jobs.vibrantm.com/job-invite/236722/
A career at Merck is an ongoing journey of discovery: our 58,000 people are
shaping how the world lives, works and plays through next generation
advancements in Healthcare, Life Science and Electronics. For more than 350
years and across the world we have passionately pursued our curiosity to find
novel and vibrant ways of enhancing the lives of others.
United As One for Patients, our purpose in Healthcare is to help create,
improve and prolong lives. We develop medicines, intelligent devices and
innovative technologies in therapeutic areas such as Oncology, Neurology and
Fertility. Our teams work together across 6 continents with passion and
relentless curiosity in order to help patients at every stage of life. Joining
our Healthcare team is becoming part of a diverse, inclusive and flexible
working culture, presenting great opportunities for personal development and
career advancement across the globe.
Your Role:
The Scientific Associate Director in Pharmacometrics (PMx) within our
Quantitative Pharmacology organization is a strategic, scientific and
cross-functional role of deploying strategic model-informed drug discovery and
development (MID3) & PMx plans. You will work in close collaboration with
colleagues within the R&D organization. This position will participate in the
Quantitative Pharmacology activities to strengthen the PMx platform
capabilities by contributing to the strategic use of modeling & simulation
(M&S) methodologies across our projects and disease areas, in alignment with
the overall clinical development plan and executing the program strategy/plan
according to appropriate timelines and involving relevant stakeholders.
This position will also be responsible for project related PMx assignments
either performed independently, under supervision or in collaboration with
external PMx CROs. You develop and implement MID3 strategies/plans fully
integrated into the overall preclinical and clinical plans. In using MID3
methodologies you strongly contribute to decision making and critical
achievements based on quantitative principles and partnering closely with
global biostatistics, clinical pharmacology expert leads, Medical Sciences,
Research, and other quantitative disciplines. You perform hands-on population
PK/PD modeling and simulation using innovative ways to support project
deliverables. Whilst initiating, coordinating and overseeing outsourced PMx
activities as needed, you strengthen and build internal PMx platform
capabilities on disease progression models. Up to date scientific development
in PMx and sharing expertise with colleagues is key as is participating in
Pharmacometrics research by developing your own innovative approach or
mentoring fellows or overlooking academic externalized works. You contribute to
external presentations and publications in the broader scientific/professional
community of clinical pharmacology and pharmacometrics and represent the
Quantitative Pharmacology entity in transactions with internal and external
stakeholders.
Who you are:
* Ideally 5+ years (Bio)pharmaceutical industry and/or postdoctoral
experiences with a doctorate (PhD, PharmD or MD) relevant in the related fields
of Pharmaceutical Sciences, Statistics or Engineering
* Hands-on experience in Pharmacometrics approaches and strategies to be
deployed in drug development programs, including but not limited to population
PK/PD, disease progression modeling, clinical trial simulations
* Profound knowledge in R and/or SAS, NONMEM or related pharmacometrics
software
* Knowledge of or ability to quickly learn the mechanism, endpoints,
progression and treatments of diseases
* Knowledge of application of AI/ML in quantitative pharmacology is a plus
* Able to present strategies and discuss outcomes of model-based approaches
via interactions with governance boards and regulatory agencies
* Promoting ambassador for MID3 internally and externally
* Proven ability of productive collaboration in a multi-discipline team,
using effective communication and taking personal accountability for timely
delivery of results
* Clear evidence of ability to make good judgement in complex situations
and adapt to changing business needs by prioritizing multiple tasks
* General knowledge of oncology, immuno-oncology, and/or immunology, and
more in depth understanding of biology and pharmacology is a plus
* Strong interpersonal skills and proactivity to cultivate a network of
productive relationships in an international matrix environment
* Outstanding presentation, communication and organization skills; ability
to lead, influence and motivate others
What we offer: With us, there are always opportunities to break new ground. We
empower you to fulfil your ambitions, and our diverse businesses offer various
career moves to seek new horizons. We trust you with responsibility early on
and support you to draw your own career map that is responsive to your
aspirations and priorities in life. Join us and bring your curiosity to life!
Curious? Apply and find more information at
https://jobs.vibrantm.com/
Regards,
Akash Khandelwal PhD
Global Head of Pharmacometrics
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