From: Johan.Rosenborg@astrazeneca.com
Subject: [NMusers] Number of compartments
Date: 2/11/2004 3:36 AM
Dear all,
Is it possible to extent the number of compartments beyond 20 by editing
appropriate program files, similar to the editing needed to extend the
maximum number of observations beyond 50?
/ Johan
>> Johan Rosenborg
>> AstraZeneca R&D Lund
>> Experimental Medicine, S-221 87 Lund, Sweden
>> Tel: +46 46 33 65 99 Fax: +46 46 33 71 91
>> E-mail: johan.rosenborg@astrazeneca.com
Number of compartments
From: Nick Holford - n.holford@auckland.ac.nz
Subject: Re: [NMusers] Number of compartments
Date: 2/11/2004 3:42 AM
Johan,
I've not tested this but I suspect if you change the parameter
PC in TSIZES, PSIZES you should be able to get more compartments.
C PC: MAX. NO. OF COMPARTMENTS (MAXIMUM IS 99)
PARAMETER (PC=20)
You will of course have to recompile all the files that depend on
TSIZES and PSIZES to make this work. The brute force way is to
recompile all the NONMEM object files in the tr and pr directories.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
From: phil.lowe@pharma.novartis.com
Subject: Re: [NMusers] Number of compartments
Date: 2/11/2004 4:31 AM
Dear Johan,
This is straightforward, as Nick has said. I have done this in order to run
physiology based PK models in NONMEM. It is fine for Monte-Carlo simulation,
but estimation can be very slow, especially if there are nonlinearities like
in blood cell binding.
Best regards, Phil.
_______________________________________________________