NONMEM mathematical background

1 messages 1 people Latest: Jun 13, 2005

NONMEM mathematical background

From: Cornebis Date: June 13, 2005 technical
From: cornebis@et.esiea.fr Subject: [NMusers] NONMEM mathematical background Date: Mon, June 13, 2005 12:33 pm Dear NM users Brand new to NONMEM, I'm looking for litterature references about the mathematical and statistical part behind NONMEM. French statistician PhD student, I'm looking for information about both : 1. the way to estimate the parameters and 2. optimal experimental design, in the very case treated by NONMEM, i.e. systems of nonlinear differential equations _which have no closed form solution. Any help much appreciated, Thank you very much for having read this e-mail ! Julien Cornebise, University Pierre et Marie Curie (Paris 6) ---------------------------------------------------------------- Groupe E.S.I.E.A. www.esiea.fr _______________________________________________________