Hello all,
I am currently trying to model data for a compound that is orally administered.
A two compartment model with FIRST order oral absorption is not describing the
data well (in my opinion). Consequently, I am attempting to model the data
using the same two compartment model except with ZERO order absorption. I am
under the impression that I am able to use ADVAN 4 TRANS 4 as well as a D1 =
theta (1). I have included a rate = - 2 for my dosing records in my data set.
My control stream is written as such:
$INPUT ID DOSE DAY TIME=TAD NTPD DV AMT COH ADDL II MDV RATE EVID CMT LDV
$SUBROUTINES ADVAN4 TRANS4
$PK
TVD1 = THETA(1)
D1 = TVD1*EXP(ETA(1))
TVCL=THETA(2)
CL=TVCL*EXP(ETA(2))
TVV2=THETA(3)
V2=TVV2*EXP(ETA(3))
TVQ = THETA(4)
Q=TVQ*EXP(ETA(4))
TVV3=THETA(5)
V3=TVV3*EXP(ETA(5))
However, I get the following error:
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
THE CHARACTERS IN ERROR ARE:
KA
196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.
NMtran failed. There is no output for model 1. Contents of FMSG:
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
THE CHARACTERS IN ERROR ARE:
KA
196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.
My question is whether I can utilize ADVAN 4 TRANS 4 to model zero order
absorption for an oral administered drug (if so, how do I address the error
listed above) OR if I have to utilize ADVAN 6?
Thanks in advance for taking time out of your busy day to help!
Regards,
Bishoy Hanna
Scientist
Celgene Corporation
179 Passaic Avenue, S11- 2645A, Summit, NJ, 07901
Phone: (908) 897 - 7733
*********************************************************
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NONMEM 2 Compartment Zero Order Absorption
you need to use ADVAN3, or
with ADAN 4 put the dose to CMT=2, define D2 (not D1) and assign and FIX KA
Leonid
Quoted reply history
On 10/1/2018 11:12 AM, Bishoy Hanna wrote:
> Hello all,
>
> I am currently trying to model data for a compound that is orally administered.
> A two compartment model with FIRST order oral absorption is not describing the
> data well (in my opinion). Consequently, I am attempting to model the data
> using the same two compartment model except with ZERO order absorption. I am
> under the impression that I am able to use ADVAN 4 TRANS 4 as well as a D1 =
> theta (1). I have included a rate = - 2 for my dosing records in my data set.
>
> My control stream is written as such:
> $INPUT ID DOSE DAY TIME=TAD NTPD DV AMT COH ADDL II MDV RATE EVID CMT LDV
> $SUBROUTINES ADVAN4 TRANS4
> $PK
> TVD1 = THETA(1)
> D1 = TVD1*EXP(ETA(1))
> TVCL=THETA(2)
> CL=TVCL*EXP(ETA(2))
> TVV2=THETA(3)
> V2=TVV2*EXP(ETA(3))
> TVQ = THETA(4)
> Q=TVQ*EXP(ETA(4))
> TVV3=THETA(5)
> V3=TVV3*EXP(ETA(5))
>
> However, I get the following error:
>
> WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
> (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
> AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
>
> THE CHARACTERS IN ERROR ARE:
> KA
> 196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.
> NMtran failed. There is no output for model 1. Contents of FMSG:
>
> WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
> (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
> AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
> THE CHARACTERS IN ERROR ARE:
> KA
> 196 $PK: NO VALUE ASSIGNED TO A BASIC PK PARAMETER.
>
> My question is whether I can utilize ADVAN 4 TRANS 4 to model zero order
> absorption for an oral administered drug (if so, how do I address the error
> listed above) OR if I have to utilize ADVAN 6?
>
> Thanks in advance for taking time out of your busy day to help!
>
> Regards,
> Bishoy Hanna
> Scientist
> Celgene Corporation
> 179 Passaic Avenue, S11- 2645A, Summit, NJ, 07901
> Phone: (908) 897 - 7733
>
> *********************************************************
> THIS ELECTRONIC MAIL MESSAGE AND ANY ATTACHMENT IS
> CONFIDENTIAL AND MAY CONTAIN LEGALLY PRIVILEGED
> INFORMATION INTENDED ONLY FOR THE USE OF THE INDIVIDUAL
> OR INDIVIDUALS NAMED ABOVE.
> If the reader is not the intended recipient, or the
> employee or agent responsible to deliver it to the
> intended recipient, you are hereby notified that any
> dissemination, distribution or copying of this
> communication is strictly prohibited. If you have
> received this communication in error, please reply to the
> sender to notify us of the error and delete the original
> message. Thank You.