Hi all
Are there any compounds or compound classes where the drug administered
in one period may produce a physiological effect which would affect the
PK of the drug administered in the next period, even if there is no PK
present at predose in the next period.
Thanks
Lata
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(no subject)
Dear Lata
If I understand correctly that you are not referring to single dose
per occasion/period, compound PK can be affected by its physiological
effects.
For example, a compound can induce its own clearance / elimination
(autoinduction) after a couple of consecutive doses.
This is particularly the case with rifamycins best exemplified by
rifampicin. Carbamazepine does the same thing.
It most cases, it takes two or more weeks for the inductive effects to
disappear. So you also need to check the washout period.
Hope this answers your question?
Hope this answers your question?
---------------------
Simba
University of Cape Town
Pharmacometrics Unit
Quoted reply history
On Thu, Sep 10, 2009 at 3:29 PM, Maganti, Lata <[email protected]> wrote:
>
> Hi all
> Are there any compounds or compound classes where the drug administered
> in one period may produce a physiological effect which would affect the
> PK of the drug administered in the next period, even if there is no PK
> present at predose in the next period.
> Thanks
> Lata
> Notice: This e-mail message, together with any attachments, contains
> information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station,
> New Jersey, USA 08889), and/or its affiliates (which may be known
> outside the United States as Merck Frosst, Merck Sharp & Dohme or
> MSD and in Japan, as Banyu - direct contact information for affiliates is
> available at http://www.merck.com/contact/contacts.html) that may be
> confidential, proprietary copyrighted and/or legally privileged. It is
> intended solely for the use of the individual or entity named on this
> message. If you are not the intended recipient, and have received this
> message in error, please notify us immediately by reply e-mail and
> then delete it from your system.
>
>