Multiple problems

From: Bill Knebel <wknebel@nih.gov> Subject: Multiple problems Date: 31 Dec 1997 14:23:47 -0500 I saw an old message in the NONMEM archive regarding multiple problems within the same run. I have a follow-up question for the NONMEM users out there. Is it possible to have more than one $TABLE step during the NONMEM run? I would like to output each problem result to a seperate table file. I am getting an error prior to the estimation step regarding one of the items in the second $TABLE step. It says the variable I am outputting is not defined in the $INPUT statement. This variable is CL,it is not in the $INPUT statement because it is being determined during the run. Any ideas? Bill Knebel, PharmD Pharmacokineticist Clinical Center Pharmacy, NIH (301) 496-0967

From: alison@c255.ucsf.EDU (ABoeckmann) Subject: Re: Multiple problems Date: 2 Jan 1998 15:52:20 -0500 Each problem in the a multi-problem run can have one or more $TABLE records. With NONMEM IV there is a known bug. In a problem subsequent to the first, a user-defined variable (such as CL) is not "remembered" by NM-TRAN from the first problem's abbreviated code. The workaround is to save the variable(s) in the NONMEM common NMPRD4. The code looks something like this example for two different PRED-defined variables. (The abbreviated code may also be in $PK and/or $ERROR blocks if PREDPP is used.) $PROBLEM first $ABBREV COMRES=2 $PRED ... X1=... X2=... COM(1)=X1 COM(2)=X2 $TABLE X1 X2 $PROBLEM second .... $TABLE COM(1)=X1 COM(2)=X2 I hope I understood it correctly. -- Alison Boeckmann