Modeling & Simulation Scientist (Nonclinical DMPK)

Modeling & Simulation Scientist (Nonclinical DMPK) About the Company Actelion (www.actelion.com) is a biopharmaceutical company founded in 1997, headquartered in Allschwil/Basel, Switzerland. Today with about 2?000 people in 28 countries we focus on discovery, development and marketing of original, innovative drugs for highly unmet medical needs. Our successfully marketed compounds are Tracleer and Ventavis for the treatment of pulmonary arterial hypertension and Zavesca, the only approved oral treatment for Gaucher disease. Actelion shares are traded as part of the blue-chip SMI (Swiss Market Index) since 2008. Actelion combines the innovation, entrepreneurial spirit and flexibility of biotech with the financial, risk management, regulatory and commercial discipline of a large pharmaceutical company. We have ambitious plans to keep improving and growing ? and are looking for people as innovative as ourselves. Job Responsibilities Providing quantitative pharmacokinetic and pharmacodynamic modelling and simulation expertise to pre-clinical project and Life cycle teams Applying quantitative PK/PD modelling and simulation to inform pre-clinical candidate selection Being a champion and advocate for pharmacometrics within the company Analyzing, interpreting and reporting pharmacokinetic and pharmacodynamic data from pre-clinical studies Performing PK/PD simulations and predicting pre-clinical and clinical PK from nonclinical data as appropriate Collaborating, mentoring and guiding other DMPK team members with pharmacometric support on their projects Interacting cross-functionally with other departments including Medical Organization, Toxicology, Formulation and Discovery Preparing and/or reviewing PK, PK/PD components of internal documents, briefing books and regulatory submission documents (e.g. IND, NDA, IB and other regulatory documents) Actively preparing, reviewing and publishing scientific papers and abstracts Representing the DMPK line on project teams Candidate Requirements PhD in relevant discipline (e.g. Quantitative Pharmacology, Pharmaceutical Sciences, Chemical Engineering) 2 to 3 years experience in Modelling and Simulation in the Pharmaceutical Industry or Contract Research Organisations Proficient in spoken and written English Strong understanding of pharmacokinetic and pharmacodynamic principles including PBPK Hands-on experience with modelling and simulation software packages (WinNonlin Phoenix, NonMEM, R, Splus) Experience with Gastroplus, SimCYP would be advantageous Must be a team player and great communicator. What Actelion Offers A competitive salary and generous social benefits The possibility for development and advancement within a constantly growing company The innovative and stimulating atmosphere of a multicultural environment The research facilities are located in Allschwil, Switzerland, a suburb of Basel close to the borders of France and Germany. The information of this email and in any file transmitted with it is strictly confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, any copying, distribution or any other use of this email is prohibited and may be unlawful. In such case, you should please notify the sender immediately and destroy this email. The content of this email is not legally binding unless confirmed by letter. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorised to state them to be the views of the sender's company. For further information about Actelion please see our website at http://www.actelion.com

Modeling & Simulation Scientist (Nonclinical DMPK) About the Company Actelion (www.actelion.com) is a biopharmaceutical company founded in 1997, headquartered in Allschwil/Basel, Switzerland. Today with about 2?000 people in 28 countries we focus on discovery, development and marketing of original, innovative drugs for highly unmet medical needs. Our successfully marketed compounds are Tracleer® and Ventavis® for the treatment of pulmonary arterial hypertension and Zavesca®, the only approved oral treatment for Gaucher disease. Actelion shares are traded as part of the blue-chip SMI® (Swiss Market Index) since 2008. Actelion combines the innovation, entrepreneurial spirit and flexibility of biotech with the financial, risk management, regulatory and commercial discipline of a large pharmaceutical company. We have ambitious plans to keep improving and growing ? and are looking for people as innovative as ourselves. Job Responsibilities Providing quantitative pharmacokinetic and pharmacodynamic modelling and simulation expertise to pre-clinical project and Life cycle teams Applying quantitative PK/PD modelling and simulation to inform pre-clinical candidate selection Being a champion and advocate for pharmacometrics within the company Analyzing, interpreting and reporting pharmacokinetic and pharmacodynamic data from pre-clinical studies Performing PK/PD simulations and predicting pre-clinical and clinical PK from nonclinical data as appropriate Collaborating, mentoring and guiding other DMPK team members with pharmacometric support on their projects Interacting cross-functionally with other departments including Medical Organization, Toxicology, Formulation and Discovery Preparing and/or reviewing PK, PK/PD components of internal documents, briefing books and regulatory submission documents (e.g. IND, NDA, IB and other regulatory documents) Actively preparing, reviewing and publishing scientific papers and abstracts Representing the DMPK line on project teams Candidate Requirements PhD in relevant discipline (e.g. Quantitative Pharmacology, Pharmaceutical Sciences, Chemical Engineering) 2 to 3 years experience in Modelling and Simulation in the Pharmaceutical Industry or Contract Research Organisations Proficient in spoken and written English Strong understanding of pharmacokinetic and pharmacodynamic principles including PBPK Hands-on experience with modelling and simulation software packages (WinNonlin Phoenix, NonMEM, R, Splus) Experience with Gastroplus, SimCYP would be advantageous Must be a team player and great communicator. What Actelion Offers A competitive salary and generous social benefits The possibility for development and advancement within a constantly growing company The innovative and stimulating atmosphere of a multicultural environment The research facilities are located in Allschwil, Switzerland, a suburb of Basel close to the borders of France and Germany. The information of this email and in any file transmitted with it is strictly confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, any copying, distribution or any other use of this email is prohibited and may be unlawful. In such case, you should please notify the sender immediately and destroy this email. The content of this email is not legally binding unless confirmed by letter. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorised to state them to be the views of the sender's company. For further information about Actelion please see our website at http://www.actelion.com