Dear all,
we are happy to announce the release of Maxsim2 2.0, which is an easy to use, intuitive, and interactive application for pharmacokinetic and pharmacodynamic simulation developed at the Fraunhofer-Chalmers Research Centre for Industrial Mathematics in close collaboration with Prof Johan Gabrielsson..
Maxsim2 provides a gallery of common PK and PD models by which one interacts using sliders, check boxes, and number fields, which in real time is mirrored in changes of concentration-time or response-time simulation profiles. This interactivity and direct visual feedback of what-if scenarios give a very good understanding of both the qualitative and quantitative impact of different parameters such as volumes of distribution, clearance, partition coefficients, potency, and dosage.
Pharmacokinetic Models:
* Physiological Models
- Tissue-Blood Drug Uptake (Human, Rat, Cat, Dog, Horse)
* Compartment Models
- One-Compartment
- Two-Compartment
- Target-mediated Drug Disposition
Pharmacodynamic Models:
* Indirect Response Models
- Inhibition of production/loss
- Stimulation of production/loss
* Instantaneous Response Models
- Ordinary Emax
- Stimulatory Sigmoidal Emax
- Inhibitory Sigmoidal Emax
Dosage regimens for the above models include any combination of user specified time scheduled i.v. bolus, i.v. infusion, and extravascular administration.
Maxsim2 are successfully used both in education and for professional applications where thorough understanding and communication of pharmacodynamic and pharmacokinetic phenomena are of importance.
A 30 days fully functional trial version can be downloaded from www.maxsim2.com < http://www.maxsim2.com >.
Enjoy!
Best regards
Mats Jirstrand
on behalf of the Maxsim2 development team