Concentration Guided Dosing
Nick Holford, MB, ChB, MSc, FRACP,
Professor Emeritus Clinical Pharmacology, Department of Pharmacology and
Clinical Pharmacology, University of Auckland, New Zealand
Wednesday March 16, 2022, 12:00 to 1:00 pm EDT
Register for free at
https://www.rosaandco.com/webinars/2022/concentration-guided-dosing
Abstract:
Individualized dosing for treatment of human disease takes many forms. Dosing
based on pharmacological principles recognizes that drug effects are caused by
drug concentration not dose. Concentration guided dosing (CGD) encompasses a
variety of approaches that are based on pharmacokinetic and pharmacodynamics
concepts even though these concepts may not be explicitly recognized. CGD may
be based on similar patient information including measured patient responses
such drug concentrations but approaches for using these responses to determine
an individualized dose have different clinical outcomes.
The two most common approaches are therapeutic drug monitoring (TDM) and target
concentration intervention (TCI). TDM is based on achieving a response within a
range (the therapeutic window) while TCI is based on achieving a single target
response. Clinical studies have shown that TCI can improve clinical outcome
while TDM does not (Holford, Ma, Metz 2020).
The webinar will explain the concept of concentration guided dosing and
illustrate the superiority of the TCI approach over the TDM approach.
Holford N, Ma G, Metz D. TDM is dead. Long live TCI! Br J Clin Pharmacol.
2020;Early View(doi:10.1111/bcp.14434).