LAST DOSE

From: "Gibiansky, Leonid" <GibiansL@globomax.com> Subject: LAST DOSE Date: Thu, 23 Sep 1999 11:45:31 -0400 Dear NONMEM users, I need to compute a recommended dose for a patient based on the last given dose and individual parameters obtained by NONMEM. Is there any easy way to have the last dose, theta, and eta parameters and use them on the finalization step to compute recommendation ? I can do it in the PK block by using current AMT. Then the output line with the last dose event will have correct answers. But in this case I need to compute PK block with every record, and the output table is messy: I can use only one line but have to output all the records for a patient. I would prefer to compute it only once for each patient, and output with the FIRSTONLY option, but then I do not have the last dose value. Is there any way around ? Thanks ! Leonid

Date: Fri, 24 Sep 1999 08:29:36 -0700 (PDT) From: ABoeckmann <alison@c255.ucsf.edu> Subject: Re: LAST DOSE My suggestion is to modify the data set before the NONMEM run. Add a data item called (say) LDOS. Record the last dose on the first event record in the LDOS item, use LDOS in the computation, and use FIRSTONLY. Another idea is to set LDOS=1 on the last dose event record, 0 on all other event records. In $PK or $ERROR, write to a file (using WRITE) when finalization and LDOS=1 Alison Boeckmann