From:"Rajeev Menon"
Subject:[NMusers] lag time
Date:Wed, February 20, 2002 4:27 pm
I am having a problem with the control stream for nonmem. The model that best
fits the data is a 2 compartment model with lag time. The nonemem model that I
am using is
> $PROBLEM POPULATION DATA FOR FLURBIPROFEN
> $INPUT ID TIME DV AMT
> $DATA NMRFLUR.csv IGNORE=C
> $SUBROUTINES ADVAN4 TRANS1
>
> $PK
> TVKA=THETA(1)
> TVK=THETA(2)
> TVK23=THETA(3)
> TVK32=THETA(4)
> TVV=THETA(5)
> TVALAG1=THETA(6)
>
> KA=TVKA*(1 + ETA(1))
> K=TVK*(1 + ETA(2))
> K23=TVK23*(1 + ETA(3))
> K32=TVK32*(1 + ETA(4))
> V=TVV*(1 + ETA(5))
> ALAG2=TVALAG1*(1+ETA(6))
> S1=V
>
> $ERROR
> Y=F*(1+ERR(1))
>
> $THETA (0,0.61) (0,0.30) (0,0.086) (0,0.157) (0,8755) (0, 0.25)
>
> $OMEGA 0.22 0.09 0.74 0.22 0.79 0.5
> $SIGMA 0.002 0.2
> $ESTIMATION MAXEVAL=9999 PRINT=5 NOABORT
> $COV
> $TABLE ID TIME AMT FILE= 1NMRFLUR.tab NOPRINT
>
I cannot get the program to run as it says the Lag statement TVALAG1 has more
than 6 characters and is an error. How can I get around this.
Thanks,
Rajeev
lag time
From:"Bachman, William"
Subject:RE: [NMusers] lag time
Date:Wed, February 20, 2002 4:38 pm
call it "TLAG1"
are you sure you want to use ALAG2?
(The lag from the depot to the central compartment is ALAG1).
Bill
From: "Bachman, William"
Subject: RE: [NMusers] lag time [2]
Date: Wed, February 20, 2002 4:45 pm
Rajeev
one other point - if your observations are in the central compartment,
you will want to define S2 (not S1)
Bill
From:"Williams, Gene M"
Subject:RE: [NMusers] lag time
Date:Wed, February 20, 2002 4:45 pm
Change "TVALAG1" to any non-reserved name of 5 characters or less.
"TVLAG1" is a name you might like...
From:"Williams, Gene M"
Subject:RE: [NMusers] lag time
Date:Wed, February 20, 2002 4:47 pm
Make that TVLG1.
From:"Atul"
Subject:Re: [NMusers] lag time
Date:Wed, February 20, 2002 5:02 pm
Hello Rajeev
Please change it to TLAG1. I think this should not cause any problem.
You can always check by simulation prior to your actual runs.
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida