Dear Colleagues,
The department of Quantitative Pharmacology and Pharmacometrics (QP2) at Merck
is looking for a pharmacometrician to join our team. Please consider applying
for the following
https://jobs.merck.com/job/Upper-Gwynedd-Senior-Scientist-PA/525279400/?feedId=232100&utm_source=Indeed&utm_campaign=Merck_Indeed&utm_source=Indeed&utm_medium=organic&utm_campaign=Indeed.
Senior Scientist/ Associate Principal Scientist, Quantitative Pharmacology and
Pharmacometrics (QP2), Merck
Requisition ID: QUA008339
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States
and Canada, is a global health care leader with a diversified portfolio of
prescription medicines, vaccines and animal health products. The difference
between potential and achievement lies in the spark that fuels innovation and
inventiveness; this is the space where Merck has codified its legacy for over a
century. Merck's success is backed by ethical integrity, forward momentum, and
an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world's premier,
most research-intensive biopharmaceutical company. Today, we're doubling down
on this goal. Merck Research Laboratories is a true scientific research
facility of tomorrow, and will take Merck's leading discovery capabilities and
world-class small molecule and biologics R&D expertise to create breakthrough
science that radically changes the way we approach serious diseases.
Senior scientists in Quantitative Pharmacology and Pharmacometrics (QP2) apply
quantitative approaches to develop and implement translational PK/PD
strategies, characterize clinical pharmacokinetics and pharmacodynamics of new
chemical entities and biologics, and inform dose selection and go/no-go
decisions.
Senior Scientists work in collaborative teams with more experienced scientists,
and are expected to have or develop expertise in one or more areas necessary to
performing primary responsibilities including:
* Being or supporting the lead representative for QP2 on drug/vaccine
development teams
* Data management and analysis
* Framing critical drug development questions for optimizing model-based
development
* Developing and executing translational PK/PD approaches, population
pharmacokinetic models, exposure-response and stratification biomarker models,
quantitative system pharmacology (QSP) and disease progression models, clinical
trial design via outcome/enrollment modeling and simulation, comparator
modeling, absorption/biopharmaceutical modeling, clinical utility index
modeling, and other model-based analyses.
Senior Scientists are expected to develop a comprehensive understanding of
global regulatory expectations for small molecules, biologics, and/or vaccines,
including support for regulatory documents (INDs, CSRs, CTDs), and agency
interactions. The Senior Scientist is a proficient modeler, is able to develop
a strong, integrated understanding of the strategic elements of drug discovery
and development, and contributes to or leads the combined efforts of QP2 and
the wider Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism
(PPDM).
Senior Scientists begin to develop leadership skills in areas such as
mentoring, managing a program (while collaborating with QP2 Program Lead),
project, or initiative. In addition to the responsibilities outlined above,
Senior Scientists demonstrate good communication skills, collaborating within
QP2 and with other functional areas, as well as with external vendors and
partners, creating an aligned, quantitative framework to impact decisions of
drug development teams.
Qualifications
Education Minimum Requirement:
* Master or equivalent degree with at least four years of experience, where
"experience" means having a record of increasing responsibility and
independence in a similar role in pharmaceutical drug development or academia.
* Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least
two years of experience or an educational background in biopharmaceutics,
pharmaceutical sciences, pharmacometrics, mathematics, statistics/
biostatistics, computational biology/chemistry, chemical/biomedical
engineering, or a related field.
Required Experience and Skills**:
* Proficiency in R, Matlab, SAS, or other similar programing language
Preferred Experience and Skills:
* Experience in performing population PK / PKPD and non-compartmental
analyses
* Experience with standard pharmacometric software (e.g. NONMEM,
Monolix, Phoenix, etc.)
* Skills in experimental design, mathematical problem solving, critical
data analysis/interpretation, and statistics
* Scientific understanding of biopharmaceutical and ADME properties
* Proficiency in written and verbal communication, interdisciplinary
collaboration, and problem scoping and planning
Your role at Merck is integral to helping the world meet new breakthroughs
that affect generations to come, and we're counting on your skills and
inventiveness to help make meaningful contributions to global medical
advancement. At Merck, we're inventing for life.
If you need assistance and/or a reasonable accommodation due to a disability
during the application or the recruiting process, please send a request to
[email protected]<mailto:[email protected]>.
Search Firm Representatives Please Read Carefully:
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for
this employment opportunity. Please, no phone calls or emails. All resumes
submitted by search firms to any employee at Merck via email, the Internet or
in any form and/or method without a valid written search agreement in place for
this position will be deemed the sole property of Merck. No fee will be paid
in the event the candidate is hired by Merck as a result of the referral or
through other means.
For more information about personal rights under Equal Employment Opportunity,
visit:
EEOC
http://www1.eeoc.gov/employers/upload/eeoc_self_print_poster.pdf
EEOC GINA Supplement
http://www1.eeoc.gov/employers/upload/eeoc_gina_supplement.pdf
OFCCP EEO
https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCP_EEO_Supplement_Final_JRF_QA_508c.pdf
Merck is an equal opportunity employer, Minority/Female/Disability/Veteran -
proudly embracing diversity in all of its manifestations.
Best Wishes,
Wei Gao, PhD
Quantitative Pharmacology & Pharmacometrics
Merck Research Laboratories
351 N Sumneytown Pike
North Wales, PA 19454
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