On behalf of Jaap Jan Boelens I would like to draw your attention to the
following position. If you are interested or have questions, please contact him
directly on the e-mail address provided below.
The adult and pediatric 'stem cell transplant and cellular therapy service',
perform combined over 250 allogeneic hematopoietic cell transplantations per
year, and over 100 cellular therapies (e.g. CART, virus spec. CTLs). We are
recruiting a 'population PK-PD' modeler to be part of a 'PK-PD and Immune
monitoring core' (which currently being developed), linked to both clinical
programs. A 'tenured track' position would be an option.
Description: We are recruiting a 'population PK-PD modeler' with special
interest in cell and gene-therapy: modeling (multi-) agents used in
conditioning, antibodies, 'immune effector cells' and immune monitoring. In the
adult and pediatric 'SCT and Cell therapy services" there is a long-standing
interest using PK-modeling to individualize treatment, to reduce toxicity and
improve efficacy. With the recent appointment of Dr JJ Boelens as new chief of
the pediatric program, the interest has further increased. Dr Boelens has
spearheaded various projects to individualize (e.g. Busulfan, ATG, Fludarabine)
and harmonize conditioning regimens aiming for better predictable immune
reconstitution and outcomes. The mission of the both services (adult and
pediatrics) is to improve survival chances and 'quality of life' of patients in
need for a cell- or gene-therapy to cure cancer (at MSK and worldwide) by
customizing / precision their treatment. To achieve this, we are building the
most innovative, flexible advanced 'Good Laboratory Practice (GLP)"-approved
"PK-PD and immune monitoring" core. By implementing state-of-the-art
technologies to measure drug levels and identify rare cell types at levels not
detectable by conventional clinical instruments, this strategy both decreases
toxicity, with minimal effect on 'quality of life', and increases the chances
of disease-free survival.
Opportunities for teaching, translational research, and multidisciplinary
collaborative projects are numerous.
Rank and salary will be based on background and experience.
Interested and qualified applicants should send their CV and bibliographies Dr
Jaap Jan Boelens (Chief of Service):
[email protected]<mailto:[email protected]>