On behalf of Jaap Jan Boelens I would like to draw your attention to the following position. If you are interested or have questions, please contact him directly on the e-mail address provided below.
The adult and pediatric 'stem cell transplant and cellular therapy service', perform combined over 250 allogeneic hematopoietic cell transplantations per year, and over 100 cellular therapies (e.g. CART, virus spec. CTLs). We are recruiting a 'population PK-PD' modeler to be part of a 'PK-PD and Immune monitoring core' (which currently being developed), linked to both clinical programs. A 'tenured track' position would be an option.
Description: We are recruiting a 'population PK-PD modeler' with special interest in cell and gene-therapy: modeling (multi-) agents used in conditioning, antibodies, 'immune effector cells' and immune monitoring. In the adult and pediatric 'SCT and Cell therapy services" there is a long-standing interest using PK-modeling to individualize treatment, to reduce toxicity and improve efficacy. With the recent appointment of Dr JJ Boelens as new chief of the pediatric program, the interest has further increased. Dr Boelens has spearheaded various projects to individualize (e.g. Busulfan, ATG, Fludarabine) and harmonize conditioning regimens aiming for better predictable immune reconstitution and outcomes. The mission of the both services (adult and pediatrics) is to improve survival chances and 'quality of life' of patients in need for a cell- or gene-therapy to cure cancer (at MSK and worldwide) by customizing / precision their treatment. To achieve this, we are building the most innovative, flexible advanced 'Good Laboratory Practice (GLP)"-approved "PK-PD and immune monitoring" core. By implementing state-of-the-art technologies to measure drug levels and identify rare cell types at levels not detectable by conventional clinical instruments, this strategy both decreases toxicity, with minimal effect on 'quality of life', and increases the chances of disease-free survival.
Opportunities for teaching, translational research, and multidisciplinary collaborative projects are numerous.
Rank and salary will be based on background and experience.
Interested and qualified applicants should send their CV and bibliographies Dr Jaap Jan Boelens (Chief of Service): boelensj_at_mskcc.org<mailto:boelensj_at_mskcc.org>