Mark your calendars for the Midwest local event of the International Society
of Pharmacometrics on Thursday 19th May, 2016 from 5.30pm to 8.00pm at
Astellas Pharma, Northbrook, IL.
Models of tumor dynamics to improve the development and use of oncology
therapeutics
By Manish Sharma, M.D.
Assistant Professor, Department of Medicine, Section of Hematology/Oncology,
University of Chicago
Agenda:
- Meet and greet with refreshments: 5:30-6:30 pm
- Presentation 6:30-7:30 pm
- Discussion 7:30 - 8:00
-
Costs: The registration fee covers refreshments.
- $5 for ISoP members and $10 for non-members
- Payment will be in cash at the event. We cannot accept credit cards.
Please register by email at <mailto:[email protected]>
[email protected] by Monday May 16th, end of business, so that we can get
an accurate headcount. If you have registered but find that you cannot
attend, please email us at <mailto:[email protected]> [email protected]
to let us know.
ISoP members receive a discount! Not yet a member? Visit www.go-isop.org
to become a member before you register for this event.
Abstract: Oncology drug development has traditionally relied on categorical
metrics of tumor response and disease progression. Longitudinal data on
tumor size and other biomarkers of disease burden can be used to develop
models of disease progression with model-based estimates of drug effect.
These models can be used to discover more powerful endpoints for clinical
trials and predictive markers of response to therapy. The potential of
these models will be discussed using examples in renal cell carcinoma,
colorectal cancer, and castrate-resistant prostate cancer.