Hi, NMusers;
I have a data set with steady state multiple dose administration at every 12
hours. However, many of the dosing intervals are not exactly 12 hours, but have
some delay. Below is an example of my data set (one TIME point is 60.9 instead
of 60). I am using SS=1 and II=12 to describe the multiple SS doses. But for
those time points with small delay, should I just ignore the time different and
still use II=12? Is this going to affect my result? Or should something else to
put in with SS and II? Thank you very much for your help.
ID,AMT,TIME,DV,MDV,SS,II
3,739,0.00,.,1,1,12
3,739,12.00,.,1,1,12
3,739,24.00,.,1,1,12
3,739,36.00,.,1,1,12
3,739,48.00,.,1,?,?
3,739,60.90,.,1,?,?
3,739,81.00,.,1,1,12
3,739,93.00,.,1,1,12
3,739,105.00,.,1,1,12
3,739,117.00,.,1,1,12
3,739,129.00,.,1,1,12
3,739,141.00,.,1,1,12
3,739,153.00,.,1,1,12
3,739,165.00,.,1,1,12
3,.,176.93,1.08,0,.,.
3,739,177.08,.,1,0,0
3,.,177.45,2.7,0,.,.
3,.,177.75,3.26,0,.,.
3,.,178.10,1.52,0,.,.
3,.,178.57,1.52,0,.,.
Min
Irregular dosing time
Hi Min,
For this data set, it's likely that there is not a large effect of a
60.9 hr dosing on the 176.93 hr sample (assuming that the half-life is
relatively short as would be usually suggested by BID dosing. It looks
like daylight savings time may have happened between the 48 and 60 hr
time points.
To save time with the model building, the simplest path would likely be
to fit using steady-state and assume that everything happened at the
nominal time (II=12) to get your model to a good state. Then, with
that good estimate, run it with the actual time for dosing. Assuming a
single-phase half-life of 12 hr, that 60.9 hr time point will not change
your sample noticeably.
Have a good day,
Bill
Quoted reply history
From: [email protected] [mailto:[email protected]]
On Behalf Of Min Dong
Sent: Monday, October 17, 2011 4:13 PM
To: [email protected]
Subject: [NMusers] Irregular dosing time
Hi, NMusers;
I have a data set with steady state multiple dose administration at
every 12 hours. However, many of the dosing intervals are not exactly 12
hours, but have some delay. Below is an example of my data set (one
TIME point is 60.9 instead of 60). I am using SS=1 and II=12 to describe
the multiple SS doses. But for those time points with small delay,
should I just ignore the time different and still use II=12? Is this
going to affect my result? Or should something else to put in with SS
and II? Thank you very much for your help.
ID,AMT,TIME,DV,MDV,SS,II
3,739,0.00,.,1,1,12
3,739,12.00,.,1,1,12
3,739,24.00,.,1,1,12
3,739,36.00,.,1,1,12
3,739,48.00,.,1,?,?
3,739,60.90,.,1,?,?
3,739,81.00,.,1,1,12
3,739,93.00,.,1,1,12
3,739,105.00,.,1,1,12
3,739,117.00,.,1,1,12
3,739,129.00,.,1,1,12
3,739,141.00,.,1,1,12
3,739,153.00,.,1,1,12
3,739,165.00,.,1,1,12
3,.,176.93,1.08,0,.,.
3,739,177.08,.,1,0,0
3,.,177.45,2.7,0,.,.
3,.,177.75,3.26,0,.,.
3,.,178.10,1.52,0,.,.
3,.,178.57,1.52,0,.,.
Min