Simcyp, the leader in mechanistic in vitro - in vivo extrapolation (IVIVE)
of pharmacokinetics invites you to register for the well-established and
renowned:
Intensive course: 'Concepts and Applications of Predicting ADME,
Pharmacokinetics and Population Variability'
19th - 23rd April 2010
London, UK
The course is comprised of lectures, delivered by leading experts in each
field of ADME, interspersed with interactive workshops centred around
practical examples demonstrating how in vitro data generated during drug
development can be used to predict:
* Metabolic drug clearance (CL)
* Metabolic drug-drug interactions (DDIs)
* Gut first-pass metabolism
* Oral drug absorption incorporating food effects and the impact of
dosage form
* Effect of transporters and enterohepatic recirculation on kinetics
* Drug distribution to different organs
* Population variability in drug concentration-time profiles
* Variation in kinetics in specific populations (paediatrics, ethnic
groups, various disease populations)
* Time-course of drug in plasma that fits observed clinical data
(achieved using fitting modules within physiologically-based
pharmacokinetics (PBPK) models combined with drug specific in vitro
information.)
The main emphasis is on using data generated in pre-clinical stages to
understand the kinetic behaviour of drugs in various target populations.
This informs decisions on the conduct and optimal design of clinical studies
with the ultimate aim of improving the quality of submissions for regulatory
approval.
The complete course runs from 19th - 23rd April at the Holiday Inn
Kensington Forum. Delegates may also choose to register for part of the
course:
* Part I: 19th - 21st April 2010
* Part II: 21st - 23rd April 2010
For further information and registration details, please visit our website
at: http://www.simcyp.com/ProductServices/Workshops/20100419_London.htm?p=1
Regards
Masoud