Hello,
Could anyone please tell me how could i use an integer function in nonmem.
I am trying to do some pop pkpd simulations
In excel when I have Tabsolute > tmax, I can convert it to time lower
than tmin by using integer function (if tabs>tmax INT(tabs-tmax)/24+1)
I then use these integer values to get the time points after 24 48 or so on
in terms of 24 hours.
t'=tabs-(integer*24)
I tried to do it by having multiple statements wherein
ABST=TIME
IF(TIME.GT.TMAX) ABST=TIME-24
IF(TIME.GT.TMAX+24) ABST=TIME-48
IF(TIME.GT.TMAX+48) ABST=TIME-72
IF(TIME.GT.TMAX+72) ABST=TIME-96
is this the only way or could i do it in some other way too.
Also could someone please explain me as to what exactly are the "newind" and
"ICALL"function. How would they help me in my simulations??
if there might be any example it would be great
Thanks a lot
Integer function and NEWIND/icall
With NONMEM VI, the INT function can be used in abbreviated code.
With earlier versions, the INT function could be used, but only in
verbatim code.
I think that this code computes ABST2 equal to ABST in your original
email:
ABST2=TIME
IF (TIME.GT.TMAX) ABST2=TIME-(INT((TIME-TMAX)/24)+1)*24
ICALL is a variable that may be tested in abbreviated code. It tells
what NONMEM is currently doing.
A test for ICALL=0 or 1 allows (e.g.) initialization of your own
variables;
a test for ICALL=3 allows (e.g.) display of your variables when the run
is finished, and so on.
A test for ICALL=4 allows you to do something different during data
simulation vs. data analysis.
If all you are doing in the current run is simulation, then do not
bother testing ICALL unless
you are forced to (e.g., because of NMTRAN error messages having to do
with nested IF statements
and random variables.)
NEWIND is a variable that may be tested in abbreviated code.It tells
where you are in the
data set: First record of the data set, start of an individual record
that is not the first, or a
data record that is not the first of any individual record.
It is not generally used in simulation, because NONMEM knows when a new
individual record starts and
change the simulated ETA's for the new individual.
THere are a number of examples of the use of NEWIND and ICALL among the
examples in Guide VIII and
on-line help.
On Tue, 13 Feb 2007 15:00:43 -0500, "navin goyal" <[EMAIL PROTECTED]>
said:
> Hello,
> Could anyone please tell me how could i use an integer function in
> nonmem.
> I am trying to do some pop pkpd simulations
> In excel when I have Tabsolute > tmax, I can convert it to time lower
> than tmin by using integer function (if tabs>tmax INT(tabs-tmax)/24+1)
> I then use these integer values to get the time points after 24 48 or so
> on
> in terms of 24 hours.
> t'=tabs-(integer*24)
>
> I tried to do it by having multiple statements wherein
> ABST=TIME
> IF(TIME.GT.TMAX) ABST=TIME-24
> IF(TIME.GT.TMAX+24) ABST=TIME-48
> IF(TIME.GT.TMAX+48) ABST=TIME-72
> IF(TIME.GT.TMAX+72) ABST=TIME-96
>
> is this the only way or could i do it in some other way too.
>
>
> Also could someone please explain me as to what exactly are the "newind"
> and
> "ICALL"function. How would they help me in my simulations??
> if there might be any example it would be great
>
> Thanks a lot
--
Alison Boeckmann
[EMAIL PROTECTED]