Installation of NM7.2 on OSX lion for dummies.

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Rob ter Heine Sent: Sunday, October 23, 2011 11:24 AM To: [email protected] Subject: [NMusers] Installation of NM7.2 on OSX lion for dummies. Dear NMUSERS, I am trying to install NM7.2 on my macbook with OSX 10.7 lion installed. I installed gfortran from this URL http://gcc.gnu.org/wiki/GFortranBinaries#MacOS I then tried installing OSX as described in the PDF readme on the installation cd, but couldn't really figure it out. My NM 7.2 CD is in the /Volumes/NONMEM_7.2.0 directory. When executing the installation command I get the error message as pasted from my terminal window below and the installation halts. Any feedback on what I'm doing wrong and getting NM7.2 installed is appreciated. Cheers! Rob ter Heine ---- MacBook-van-Rob-ter-Heine:NONMEM_7.2.0 robterheine$ /bin/bash SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i NONMEM 7.2.0 INSTALLATION UTILITY - UNIX Bourne-Again SHell version For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i default nonmem72e.zip nonmem72r.zip CD-ROM drive is /Volumes/NONMEM_7.2.0 NONMEM 7.2 directory is /opt/nm72 Command for FORTRAN compiles is gfortran Optimization for Fortran compiles is y Command to build NONMEM archive is ar Sizes is same (SIZES.f90 is always used) Recompile is rec All binaries will be recompiled Interactive is i Unzip program is unzip Encrypted source file is nonmem72e.zip Unencrypted file is nonmem72r.zip To learn how to override the defaults, enter % SETUP72 help Continue (y/n) [y]?y The directory /opt/nm72 does not exist. Step 1. Creating /opt/nm72 mkdir: /opt: No such file or directory Cannot create /opt/nm72 ________________________________ De informatie in dit e-mail bericht is uitsluitend bestemd voor de geadresseerde. Verstrekking aan en gebruik door anderen is niet toegestaan. Door de elektronische verzending van het bericht kunnen er geen rechten worden ontleend aan de informatie. ________________________________ Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.

On Oct 23, 2011, at 5:24 PM, Rob ter Heine wrote: > Dear NMUSERS, > > I am trying to install NM7.2 on my macbook with OSX 10.7 lion installed. I > installed gfortran from this URL > http://gcc.gnu.org/wiki/GFortranBinaries#MacOS > > I then tried installing OSX as described in the PDF readme on the > installation cd, but couldn’t really figure it out. My NM 7.2 CD is in the > /Volumes/NONMEM_7.2.0 directory. When executing the installation command I > get the error message as pasted from my terminal window below and the > installation halts. Any feedback on what I’m doing wrong and getting NM7.2 > installed is appreciated. > > Cheers! > > Rob ter Heine > > ---- > > MacBook-van-Rob-ter-Heine:NONMEM_7.2.0 robterheine$ /bin/bash SETUP72 > /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i > NONMEM 7.2.0 INSTALLATION UTILITY - UNIX Bourne-Again SHell version > For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD > > SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i default > nonmem72e.zip nonmem72r.zip > CD-ROM drive is /Volumes/NONMEM_7.2.0 > NONMEM 7.2 directory is /opt/nm72 > Command for FORTRAN compiles is gfortran > Optimization for Fortran compiles is y > Command to build NONMEM archive is ar > Sizes is same (SIZES.f90 is always used) > Recompile is rec > All binaries will be recompiled > Interactive is i > Unzip program is unzip > Encrypted source file is nonmem72e.zip > Unencrypted file is nonmem72r.zip > > To learn how to override the defaults, enter > % SETUP72 help > > Continue (y/n) [y]?y > > The directory /opt/nm72 does not exist. > Step 1. Creating /opt/nm72 > mkdir: /opt: No such file or directory > Cannot create /opt/nm72 > De informatie in dit e-mail bericht is uitsluitend bestemd > voor de geadresseerde. Verstrekking aan en gebruik door > anderen is niet toegestaan. Door de elektronische verzending > van het bericht kunnen er geen rechten worden ontleend aan de > informatie. -- Justin Wilkins, PhD Exprimo NV Tel: +41 (0) 81 599 23 82 Mobile: +41 (0) 76 561 09 49 E-mail: [email protected] Web: www.exprimo.com This e-mail is confidential. It is also privileged or otherwise protected by work product immunity or other legal rules. The information is intended to be for use of the individual or entity named above. If you are not the intended recipient, please be aware that any disclosure, copying, distribution or use of the contents of this information is prohibited. You should therefore delete this message from your computer system. If you have received the message in error, please notify us by reply e-mail. The integrity and security of this message cannot be guaranteed on the Internet. Thank you for your co-operation.

From: [email protected] [mailto:[email protected]] On Behalf Of Rob ter Heine Sent: Sunday, October 23, 2011 11:24 AM To: [email protected] Subject: [NMusers] Installation of NM7.2 on OSX lion for dummies. Dear NMUSERS, I am trying to install NM7.2 on my macbook with OSX 10.7 lion installed. I installed gfortran from this URL http://gcc.gnu.org/wiki/GFortranBinaries#MacOS I then tried installing OSX as described in the PDF readme on the installation cd, but couldn't really figure it out. My NM 7.2 CD is in the /Volumes/NONMEM_7.2.0 directory. When executing the installation command I get the error message as pasted from my terminal window below and the installation halts. Any feedback on what I'm doing wrong and getting NM7.2 installed is appreciated. Cheers! Rob ter Heine ---- MacBook-van-Rob-ter-Heine:NONMEM_7.2.0 robterheine$ /bin/bash SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i NONMEM 7.2.0 INSTALLATION UTILITY - UNIX Bourne-Again SHell version For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i default nonmem72e.zip nonmem72r.zip CD-ROM drive is /Volumes/NONMEM_7.2.0 NONMEM 7.2 directory is /opt/nm72 Command for FORTRAN compiles is gfortran Optimization for Fortran compiles is y Command to build NONMEM archive is ar Sizes is same (SIZES.f90 is always used) Recompile is rec All binaries will be recompiled Interactive is i Unzip program is unzip Encrypted source file is nonmem72e.zip Unencrypted file is nonmem72r.zip To learn how to override the defaults, enter % SETUP72 help Continue (y/n) [y]?y The directory /opt/nm72 does not exist. Step 1. Creating /opt/nm72 mkdir: /opt: No such file or directory Cannot create /opt/nm72 _____ De informatie in dit e-mail bericht is uitsluitend bestemd voor de geadresseerde. Verstrekking aan en gebruik door anderen is niet toegestaan. Door de elektronische verzending van het bericht kunnen er geen rechten worden ontleend aan de informatie. _____

Van: Justin Wilkins [mailto:[email protected]] Verzonden: woensdag 26 oktober 2011 17:56 Aan: Heine, R. ter (Apotheek Algemeen/Management) CC: [email protected] Onderwerp: Re: [NMusers] Installation of NM7.2 on OSX lion for dummies. Dear Rob, There are a couple of steps you need to perform to prepare your computer's folder structure - in your case, it looks like /opt does not exist. Create it using sudo mkdir /opt and set appropriate permissions using sudo chown -R <username> /opt (where <username> is your username, without brackets) before finally running SETUP72 as you had it. That should fix the issue. If you install MPICH2 for parallel NONMEM execution, I would be very interested in your experiences (as well as those of any others who've tried it). We have had some odd problems using it under Mac OS X (mainly, non-reproducible results with numerically complex models), although it seems to work fine under the Windows and Linux systems we tested with the same compiler (Intel Visual Fortran). We saw the issue with a range of different compiler switches. Best Justin On Oct 23, 2011, at 5:24 PM, Rob ter Heine wrote: Dear NMUSERS, I am trying to install NM7.2 on my macbook with OSX 10.7 lion installed. I installed gfortran from this URL http://gcc.gnu.org/wiki/GFortranBinaries#MacOS I then tried installing OSX as described in the PDF readme on the installation cd, but couldn't really figure it out. My NM 7.2 CD is in the /Volumes/NONMEM_7.2.0 directory. When executing the installation command I get the error message as pasted from my terminal window below and the installation halts. Any feedback on what I'm doing wrong and getting NM7.2 installed is appreciated. Cheers! Rob ter Heine ---- MacBook-van-Rob-ter-Heine:NONMEM_7.2.0 robterheine$ /bin/bash SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i NONMEM 7.2.0 INSTALLATION UTILITY - UNIX Bourne-Again SHell version For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i default nonmem72e.zip nonmem72r.zip CD-ROM drive is /Volumes/NONMEM_7.2.0 NONMEM 7.2 directory is /opt/nm72 Command for FORTRAN compiles is gfortran Optimization for Fortran compiles is y Command to build NONMEM archive is ar Sizes is same (SIZES.f90 is always used) Recompile is rec All binaries will be recompiled Interactive is i Unzip program is unzip Encrypted source file is nonmem72e.zip Unencrypted file is nonmem72r.zip To learn how to override the defaults, enter % SETUP72 help Continue (y/n) [y]?y The directory /opt/nm72 does not exist. Step 1. Creating /opt/nm72 mkdir: /opt: No such file or directory Cannot create /opt/nm72 ________________________________ De informatie in dit e-mail bericht is uitsluitend bestemd voor de geadresseerde. Verstrekking aan en gebruik door anderen is niet toegestaan. Door de elektronische verzending van het bericht kunnen er geen rechten worden ontleend aan de informatie. ________________________________ -- Justin Wilkins, PhD Exprimo NV Tel: +41 (0) 81 599 23 82 Mobile: +41 (0) 76 561 09 49 E-mail: [email protected] Web: www.exprimo.com http://www.exprimo.com/ This e-mail is confidential. It is also privileged or otherwise protected by work product immunity or other legal rules. The information is intended to be for use of the individual or entity named above. If you are not the intended recipient, please be aware that any disclosure, copying, distribution or use of the contents of this information is prohibited. You should therefore delete this message from your computer system. If you have received the message in error, please notify us by reply e-mail. The integrity and security of this message cannot be guaranteed on the Internet. Thank you for your co-operation. ***************************DISCLAIMER**************************** De informatie in dit e-mail bericht is uitsluitend bestemd voor de geadresseerde. Verstrekking aan en gebruik door anderen is niet toegestaan. Door de elektronische verzending van het bericht kunnen er geen rechten worden ontleend aan de informatie.

On 27/10/2011, at 1:55 AM, Justin Wilkins wrote: > Dear Rob, > > There are a couple of steps you need to perform to prepare your computer's > folder structure - in your case, it looks like /opt does not exist. Create it > using > > sudo mkdir /opt > > and set appropriate permissions using > > sudo chown -R <username> /opt > > (where <username> is your username, without brackets) before finally running > SETUP72 as you had it. That should fix the issue. > > If you install MPICH2 for parallel NONMEM execution, I would be very > interested in your experiences (as well as those of any others who've tried > it). We have had some odd problems using it under Mac OS X (mainly, > non-reproducible results with numerically complex models), although it seems > to work fine under the Windows and Linux systems we tested with the same > compiler (Intel Visual Fortran). We saw the issue with a range of different > compiler switches. > > Best > Justin > > On Oct 23, 2011, at 5:24 PM, Rob ter Heine wrote: > >> Dear NMUSERS, >> >> I am trying to install NM7.2 on my macbook with OSX 10.7 lion installed. I >> installed gfortran from this URL >> http://gcc.gnu.org/wiki/GFortranBinaries#MacOS >> >> I then tried installing OSX as described in the PDF readme on the >> installation cd, but couldn’t really figure it out. My NM 7.2 CD is in the >> /Volumes/NONMEM_7.2.0 directory. When executing the installation command I >> get the error message as pasted from my terminal window below and the >> installation halts. Any feedback on what I’m doing wrong and getting NM7.2 >> installed is appreciated. >> >> Cheers! >> >> Rob ter Heine >> >> ---- >> >> MacBook-van-Rob-ter-Heine:NONMEM_7.2.0 robterheine$ /bin/bash SETUP72 >> /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i >> NONMEM 7.2.0 INSTALLATION UTILITY - UNIX Bourne-Again SHell version >> For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD >> >> SETUP72 /Volumes/NONMEM_7.2.0 /opt/nm72 gfortran y ar same rec i default >> nonmem72e.zip nonmem72r.zip >> CD-ROM drive is /Volumes/NONMEM_7.2.0 >> NONMEM 7.2 directory is /opt/nm72 >> Command for FORTRAN compiles is gfortran >> Optimization for Fortran compiles is y >> Command to build NONMEM archive is ar >> Sizes is same (SIZES.f90 is always used) >> Recompile is rec >> All binaries will be recompiled >> Interactive is i >> Unzip program is unzip >> Encrypted source file is nonmem72e.zip >> Unencrypted file is nonmem72r.zip >> >> To learn how to override the defaults, enter >> % SETUP72 help >> >> Continue (y/n) [y]?y >> >> The directory /opt/nm72 does not exist. >> Step 1. Creating /opt/nm72 >> mkdir: /opt: No such file or directory >> Cannot create /opt/nm72 >> De informatie in dit e-mail bericht is uitsluitend bestemd >> voor de geadresseerde. Verstrekking aan en gebruik door >> anderen is niet toegestaan. Door de elektronische verzending >> van het bericht kunnen er geen rechten worden ontleend aan de >> informatie. > > -- > > Justin Wilkins, PhD > > Exprimo NV > > Tel: +41 (0) 81 599 23 82 > Mobile: +41 (0) 76 561 09 49 > E-mail: [email protected] > Web: www.exprimo.com > > This e-mail is confidential. It is also privileged or otherwise protected by > work product immunity or other legal rules. The information is intended to be > for use of the individual or entity named above. If you are not the intended > recipient, please be aware that any disclosure, copying, distribution or use > of the contents of this information is prohibited. You should therefore > delete this message from your computer system. If you have received the > message in error, please notify us by reply e-mail. The integrity and > security of this message cannot be guaranteed on the Internet. > > Thank you for your co-operation. >