Dear NMUsers
I'm learning to use PRIOR subroutine in NONMEM.I followed 'NONMEM USERS GUIDE
INTRODUCTION TO NONMEM 7.3.0(P77)' and it says: The $OMEGA records list the
variances, in order, the following:
NETAxNETA of initial OMEGAS
NTHPxNTHP of variances of Priors to THETAS
NETPxNETP of priors to OMEGAS, matching the block pattern of the
initial OMEGAS
And an example is given: $OMEGA BLOCK(4) ; Variance to prior information of
THETAS (NTHPxNTHP=4x4 of them). 10000 FIX 0.00 10000 0.00 0.00 10000
0.00 0.00 0.0 10000Now my question is:1) What does 'variance' mean here? Is it
the statistical terminology 'variance'? 2)Where can I find this variance?(i.e.
10000 in the matrix above) Perhaps from the output file of previous study? 3)Do
the off-diagonal elements have to be 0?(This Guide gives multiple examples,
where all the off-diagonal elements are set to 0) If not, what values should I
set?
I would be very grateful for any guidances and discussion on $PRIORMany
Thanks!Rong Chen