how to implement AR residual error model in Nonmem with FOCE INT routine

1 messages 1 people Latest: Jan 06, 2010
Hello Nonmem Users, Is there a more detailed explanation of the code in http://cognigencorp.com/nonmem/nm/97dec172003.html somwhere? I try to implement a second-order autoregressive process. If C(J,1) is a correlation coefficient, can I use more complex equations for C(j,1)? Will this code work if we use ADVAN13 (PD model here)? Thanks! Pavel
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----- Original Message ----- From: Gastonguay, Marc Date: Tuesday, December 29, 2009 10:09 am Subject: Re: [NMusers] how to implement AR residual error model in Nonmem with FOCE INT routine To: Ethan Wu Cc: nmusers > Hello Ethan, > This archived NMusers discussion thread might be useful: > > http://cognigencorp.com/nonmem/nm/97dec172003.html > > Marc > > Marc R. Gastonguay, Ph.D. > President & CEO, Metrum Research Group LLC < metrumrg.com > > Scientific Director, Metrum Institute < metruminstitute.org > > 2 Tunxis Rd, Suite 112, Tariffville, CT 06081 Direct: > +1.860.670.0744 Main: +1.860.735.7043 Fax: +1.860.760.6014 > > > > On Dec 29, 2009, at 9:14 AM, Ethan Wu wrote: > > > Dear all, > > I am fitting a PK/PD model using FOCE INT. I do see a high > > > correlation between WRES > > I wonder could someone help me with implementation of AR > residual > > error model in NONMEM. > > Many thanks! Happy new year to all. > > > > > >