Help please...

From: "Mike Cole" <Michael.Cole@newcastle.ac.uk> Subject: Help please... Date: Wed, 13 Dec 2000 10:52:01 +0000 Hello Any help or advise would be much appreciated. I am using a straightforward 2 compartment model to obtain 'empirical bayes' (posthoc) estimates of clearance for new patients based upon 1 or 2 data points for that individual together with data from 60 patients for which we have 6/7 data points per individual. I would like to produce a graph showing the observed data for the new individual together with predictions based upon the 'empirical bayes' estimates for that patient. If I append the data file with dummy time points which have missing dependent variables the estimates become nonsensical. Can anyone explain why this happens or suggest a simple alternative. Thanks in advance. Mike Cole ________________________________________________ Michael Cole Dept of Statistics/Cancer Research Unit, Merz Court, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK Tel: 0191 222 7209 (Stats)/ 0191 222 7134 (CRU) Fax: 0191 222 8020

From: Mats Karlsson <Mats.Karlsson@biof.uu.se> Subject: Re: Help please... Date: Wed, 13 Dec 2000 12:15:27 +0100 Hi Mike, If you create an EVID column in your data file and give EVID the value of: 0 for true observations 1 for dose 2 for dummy points, you should obtain what you want. Best regards, Mats -- Mats Karlsson, PhD Professor of Biopharmaceutics and Pharmacokinetics Div. of Biopharmaceutics and Pharmacokinetics Dept of Pharmacy Faculty of Pharmacy Uppsala University Box 580 SE-751 23 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@biof.uu.se