Dear all:
I attached three files with this email, one data file and two
control files, when I run .ctl file with nmvi.pl (with NMQual
installation), the program always stop at the end of first patient,
cursor flash, no further work. Could some people help me with this
situation. Program run well with
ordinary NONMEM, I mean without NMQual installation on another
computer. I appreciate your consideration and help.
Lu
CS3_IVINFEST.csv
Description:
MS-Excel spreadsheet
$PROBLEM PROJECT singledose i.v infusion ;DATE 6-2-04 PROGRAMMER:XXXX
;UNITS: Time=hour, Concentration=ng/ml
;Dose=100mg, Clearance=L/hr, Volume = L
$INPUT ID TIME CONC=DV AMT RATE MDV
$DATA cs3_ivinfest.csv IGNORE=C
;RATE specifies the infusion rate, for a dose of 100mg, rate of 16.7mg/hr
;means infusion for 6hrs
$SUBROUTINE ADVAN1 TRANS2 ;A one compartment model from PREDPP library
$PK
FLG1=0
FLG2=0
FLG3=0
FLG4=0
FLG5=0
FLG6=0
FLG7=0
FLG8=0
FLG9=0
FLG10=0
FLG11=0
FLG12=0
FLG13=0
FLG14=0
FLG15=0
FLG16=0
FLG17=0
FLG18=0
FLG19=0
FLG20=0
IF (ID .EQ. 1) FLG1=1
IF (ID .EQ. 2) FLG2=1
IF (ID .EQ. 3) FLG3=1
IF (ID .EQ. 4) FLG4=1
IF (ID .EQ. 5) FLG5=1
IF (ID .EQ. 6) FLG6=1
IF (ID .EQ. 7) FLG7=1
IF (ID .EQ. 8) FLG8=1
IF (ID .EQ. 9) FLG9=1
IF (ID .EQ. 10) FLG10=1
IF (ID .EQ. 11) FLG11=1
IF (ID .EQ. 12) FLG12=1
IF (ID .EQ. 13) FLG13=1
IF (ID .EQ. 14) FLG14=1
IF (ID .EQ. 15) FLG15=1
IF (ID .EQ. 16) FLG16=1
IF (ID .EQ. 17) FLG17=1
IF (ID .EQ. 18) FLG18=1
IF (ID .EQ. 19) FLG19=1
IF (ID .EQ. 20) FLG20=1
CL =
THETA(1)*FLG1+THETA(2)*FLG2+THETA(1)*FLG1+THETA(1)*FLG1+THETA(1)*FLG1+THETA(1)*FLG1+THETA(1)*FLG1+THETA(1)*FLG1
;Clearance in L/hr
V = THETA(2) ;Volume of distribution in L
S1 =V/1000 ;scaling factor to match concentration in ng/ml
$ERROR
IPRED=F
Y=F+F*ERR(1)+ERR(2) ;Combined residual error model
$THETA (5,25) ;POPCL
$THETA (10,86) ;POPV
$OMEGA 0.02
$OMEGA 10
;$OMEGA 0.09 ;BSVCL ;30% BSV for Clearance
;$OMEGA 0.09 ;BSVV ;30% BSV for volume
;$SIGMA 0.02 ;ERRCV ;Proportional error = 15%
;$SIGMA 10 ;ERRSD ;Additive error =3ng/ml
$ESTIMATION METHOD=0 MAXEVAL=9999 PRINT=10 NOABORT
$COVARIANCE SPECIAL PRINT=E
$TABLE ID TIME DV IPRED AMT CL V NOPRINT ONEHEADER FILE= cs3_ivinfestind.fit
INCLUDE CS3_IVINFESTIND2.txt 19
$PROBLEM PROJECT singledose i.v infusion ;DATE 6-2-04 PROGRAMMER:XXXX
;UNITS: Time=hour, Concentration=ng/ml
;Dose=100mg, Clearance=L/hr, Volume = L
$INPUT ID TIME CONC=DV AMT RATE MDV
$DATA cs3_ivinfest.csv IGNORE=C RECS=ID NOREWIND
;RATE specifies the infusion rate, for a dose of 100mg, rate of 16.7mg/hr
;means infusion for 6hrs
$THETA (5,25) ;POPCL
$THETA (10,86) ;POPV
$OMEGA 0.02
$OMEGA 10
;$OMEGA 0.09 ;BSVCL ;30% BSV for Clearance
;$OMEGA 0.09 ;BSVV ;30% BSV for volume
;$SIGMA 0.02 ;ERRCV ;Proportional error = 15%
;$SIGMA 10 ;ERRSD ;Additive error =3ng/ml
$ESTIMATION METHOD=0 MAXEVAL=9999 PRINT=10 NOABORT
$COVARIANCE SPECIAL PRINT=E
$TABLE ID TIME DV IPRED AMT CL V NOPRINT NOHEADER FORWARD FILE=
cs3_ivinfestind.fit