From: "Sreenivasa Rao Vanapalli" <svanapal@blue.weeg.uiowa.edu>
Subject: Error Messgae
Date: Wed, 16 May 2001 09:19:57 -0500
I'm getting this message: Please someone interpret this for me.
MONITORING OF SEARCH:
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 7 ID= .21000000E+02 (WITHIN-INDIVIDUAL) DATA REC NO.
22
THETA=
3.00E-01 8.00E-01 1.00E-01 1.00E-02 1.30E+01 1.00E-03 2.00E+02
1.00E+00 5.00E+00 1.50E-01
NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.
NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR TO DIFFERENTIAL
EQUATIONS, 5, MAY BE TOO LARGE.
0PROGRAM TERMINATED BY OBJ
MESSAGE ISSUED FROM ESTIMATION STEP
AT INITIAL OBJ. FUNCTION EVALUATION
1THERE ARE ERROR MESSAGES IN FILE PRDERR
Regards
Sreenivasa Rao Vanapalli, Ph.D,
Janssen Postdoctoral Research Scholar,
S411 PHAR, College of Pharmacy,
University of Iowa, Iowa City, IA-52242
319-353-5157 (Office)
319-337-2687 (Home)
Error Messgae
From: "Bachman, William" <bachmanw@globomax.com>
Subject: RE: Error Messgae -> NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE
Date: Wed, 16 May 2001 10:38:24 -0400
NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE means, well, it's having problems with the numerical integration!
You basically have a few choices:
1. Change the relative tolerance, TOL, from 5 to a number requiring fewer significant figures, e.g. 3
2. Try a different numerical integration algorithm, e.g. if you are using ADVAN6, try ADVAN8 or ADVAN9.
3. Your model is too complex, make it simpler.
Bill
From: "Ziad Hussein" <zhussein@medeval.com>
Subject: RE: Error Messgae
Date: Wed, 16 May 2001 15:55:53 +0100
Dear Sreenivasa,
Try to reduce TOL from 5 to 3 or use ADVAN8 or ADVAN9.
Regards,
Dr Ziad Hussein
Head of Pharmacokinetics
Medeval Ltd
Skelton House
Manchester Science Park
Lloyd Street North
Manchester, UK
Tel: xx-44-161-226 6525 (Ext 295)