From: Jiun-Li Jang <jjang@voicenet.com>
Subject: Error message 72
Date: Tue, 31 Jul 2001 22:59:29 -0400
Dear all,
I am a new NM user, I started my first NM study recently and encountered
a problem (floating error-overflow; Error message 72). I need your help
to direct me how to resolve this problem. I have tried to change omega
and sigma values, comma out the ALAG1 and ETA3. I have also tried to
change the boundary conditions (enlarged or decreased). The error
message was always shown, then the program was stopped. Very few times
I could get the table in the directory but not output file if I was not
kicked out in the begining. I realized that the number of subjects may
not be enough to conduct population PK analysis, it was just a try, if
the model works, then I'll add more subjects. Please find the attached
control file and data file, I thank you in advance for taking your time
and effort to teach me.
J.J.
Error message 72
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com>
Subject: RE: Error message 72
Date: Wed, 1 Aug 2001 10:11:40 +0200
Jiun-Li,
I think you have a typo in your control stream. ALAG1 should be as follows:
ALAG1=THETA(6)*EXP(ETA(3))
After correction, convergence is achieved (see the output attached).
Best regards,
Vladimir
------------------------------------------------------------------------
Vladimir Piotrovsky, Ph.D.
Research Fellow
Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463)
Janssen Research Foundation
B-2340 Beerse
Belgium
Email: vpiotrov@janbe.jnj.com