Dear NONMEM user,
This may be an old topic. I newly subscribed to the mail list and I searched
the archives, but could not find the related answer.
We have a compound, which showed a more-than-dose-proportional increase in SAD.
The slope from power model was ~1.4, the half-life is consistent in all the
cohorts though. Also in MAD, the accumulation was less than expected. Could you
please kindly instruct me how to incorporate these two factors in the NONMEM?
I really appreciate your help!
Regards,
Xiaolu