different results from two computers

From: "Zheng_Jenny" Zheng_Jenny@allergan.com Subject: [NMusers] different results from two computers Date: Mon, 14 Aug 2006 21:05:00 -0700 Dear all, I have tried to run the same control file in two computers. One run minimized successfully and another failed with the following message: forrtl:error (73): floating divide by zero Image PC Routine Line Source run_test.ext 004014C2 Unknown Unknown Unknnow run_test.ext 00406947 Unknown Unknown Unknnow run_test.ext 00454679 Unknown Unknown Unknnow run_test.ext 0045CF46 Unknown Unknown Unknnow run_test.ext 004264C2 Unknown Unknown Unknnow run_test.ext 0041BF17 Unknown Unknown Unknnow Estimation omitted. Would you please comment on the situation and more importantly, provide some advice? Thanks, Jenny

From: Mark Sale - Next Level Solutions com Subject: RE: [NMusers] different results from two computers Date: Wed, 16 Aug 2006 04:57:22 -0700 Nick et al Update on the stability of NONMEM/importance of successful minimization. After fixing a problem with the summation of the likelihood, we have managed to make NONMEM converge successfully indenpendent of sequence of subjects. You may recall the discussion that, for one problem at least, whether NONMEM converged was dependent on the sequence of subjects in the data set. Nick (appropriately) cited this as some evidence of the lack of importance of successful minimization, since for this this problem at least it seemed to be a random event (since the sequence of subjects was randomly defined). We seemed to have solved that source of instability in NONMEM with some fairly simple changes in the code, and now have a version of NONMEM VI where convergence is independent of sequence of subjects in the data set, and is essentially the best case from the 100 native NONMEM runs. Perhaps eventually, other sources of numerical instability will be identified and we can all agree that minimization really does mean something about the quality of the model/data set. I'll post the results of the native NONMEM and the modified NONMEM on my web site (www.NextLevelSolns.com/downloads) probably tomorrow. I'm looking for cases to try where this approach will make models that refused to do a covariance step now will do one. Anyone with interesting, relatively fast problems (< 10 minutes) that fail covariance, please contact me. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com

From: "jiang zhigang" jiangzhigangchn@hotmail.com Subject: RE: [NMusers] different results from two computers Date: Wed, 16 Aug 2006 23:02:23 +0800 Hi,Jenny I think the problem is the version of your compiler is old! Upgrade it! I hope this can help you! Good Luck! Jiang _______________________________________________________

From: "Nandy, Partha [PRDUS]" PNandy@prdus.jnj.com Subject: RE: [NMusers] different results from two computers Date: Fri, 18 Aug 2006 17:17:35 -0400 Hi Mark, Is this fix that you are talking about work for NONMEM V as well? I have several of the kind that you are interested in from NM-V, but none from NONMEM VI.. If you think it will be helpful, I can share some of these with you. Kind Regards, Partha