Data set structure for dose and dosing period alteration in multiple IV dosing

1 messages 1 people Latest: Aug 29, 2012
Dear NMusers, I am working on a data set that we received from a local hospital. Some of these patients received 400/500/600 mg IV infusions (30 mins) for every 12 hrs. However in few of these patients the dose was altered after couple of days (600 decreased to 400mg) or the frequency was adjusted to 18 hrs . How we have to create the dose records for these patients. Since the dose,dosing period is not similar for all the patients, how we can evaluate and validate the model? ID TIME AMT ADDL II RATE DUR DV EVID MDV 1 0 500 19 12 1000 0.5 . 1 1 Thank you very much for your feedback in advance. Regards, Shankar Lanke Ph.D.