Dear all,
I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx-pop library,
...........
CL=THETA(1)*EXP(ETA(1))
V2=THETA(2)*EXP(ETA(2))
Q =THETA(3)*EXP(ETA(3))
V3=THETA(4)*EXP(ETA(4))
KA=THETA(5)*EXP(ETA(5))
R2=THETA(6)*EXP(ETA(6))
F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
F2=1-F1
S2=V2
.................
and for each dose record, an additional IV adminstration dose record
is inserted with same dosage & rate=-2
ID TIME AMT DV CMT RATE........
1 0 100 . 1 0 .........
1 0 100 . 2 -2 .........
An error message is reported 'PK PARAMETER FOR DURATION IS NOT
SUPPLIED BY PK FOR COMPT. NO. 2'.
So is it the proper way to code the data? How can I estimate combined
absorption model without using the differiential equation?
Many thanks for your help!
BR,
Galadriel
Combined absorption model
Dear Galadriel
I think you need to change your
R2=THETA(6)*EXP(ETA(6))
to
D2=THETA(6)*EXP(ETA(6))
in order estimated the duration of your zero order absorption.
BR
Kim
Quoted reply history
-----Original Message-----
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] Behalf Of Galadriel
Sent: den 21 juli 2008 11:8
To: [email protected]
Subject: [NMusers] Combined absorption model
Dear all,
I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx-pop library,
...........
CL=THETA(1)*EXP(ETA(1))
V2=THETA(2)*EXP(ETA(2))
Q =THETA(3)*EXP(ETA(3))
V3=THETA(4)*EXP(ETA(4))
KA=THETA(5)*EXP(ETA(5))
R2=THETA(6)*EXP(ETA(6))
F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
F2=1-F1
S2=V2
.................
and for each dose record, an additional IV adminstration dose record
is inserted with same dosage & rate=-2
ID TIME AMT DV CMT RATE........
1 0 100 . 1 0 .........
1 0 100 . 2 -2 .........
An error message is reported 'PK PARAMETER FOR DURATION IS NOT
SUPPLIED BY PK FOR COMPT. NO. 2'.
So is it the proper way to code the data? How can I estimate combined
absorption model without using the differiential equation?
Many thanks for your help!
BR,
Galadriel
Dear Galadriel,
When the RATE data item is coded "-2", then you should estimate D2 (duration
for the central compartment), instead of R2.
Howard Lee
Quoted reply history
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Galadriel
Sent: Monday, July 21, 2008 5:08 AM
To: [email protected]
Subject: [NMusers] Combined absorption model
Dear all,
I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx-pop library,
...........
CL=THETA(1)*EXP(ETA(1))
V2=THETA(2)*EXP(ETA(2))
Q =THETA(3)*EXP(ETA(3))
V3=THETA(4)*EXP(ETA(4))
KA=THETA(5)*EXP(ETA(5))
R2=THETA(6)*EXP(ETA(6))
F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
F2=1-F1
S2=V2
.................
and for each dose record, an additional IV adminstration dose record
is inserted with same dosage & rate=-2
ID TIME AMT DV CMT RATE........
1 0 100 . 1 0 .........
1 0 100 . 2 -2 .........
An error message is reported 'PK PARAMETER FOR DURATION IS NOT
SUPPLIED BY PK FOR COMPT. NO. 2'.
So is it the proper way to code the data? How can I estimate combined
absorption model without using the differiential equation?
Many thanks for your help!
BR,
Galadriel
Dear Galadriel:
You would need to provide an estimate of D2, the duration of zero-order input to CMT=2 in your model.
Sam Liao
Pharmax Research
> Dear all,
>
> I tried to build up a combined absorption model (zero order + first
> order)using ADVAN 4, following is the control file I found in the
> PDx-pop library,
>
> ...........
> CL=THETA(1)*EXP(ETA(1))
> V2=THETA(2)*EXP(ETA(2))
> Q =THETA(3)*EXP(ETA(3))
> V3=THETA(4)*EXP(ETA(4))
> KA=THETA(5)*EXP(ETA(5))
> R2=THETA(6)*EXP(ETA(6))
> F1=EXP(THETA(7)+ETA(7))/(1+EXP(THETA(7)+ETA(7)))
> F2=1-F1
> S2=V2
> .................
>
> and for each dose record, an additional IV adminstration dose record
> is inserted with same dosage & rate=-2
>
> ID TIME AMT DV CMT RATE........
> 1 0 100 . 1 0 .........
> 1 0 100 . 2 -2 .........
>
> An error message is reported 'PK PARAMETER FOR DURATION IS NOT
> SUPPLIED BY PK FOR COMPT. NO. 2'.
>
> So is it the proper way to code the data? How can I estimate combined
> absorption model without using the differiential equation?
>
> Many thanks for your help!
>
> BR,
> Galadriel