Career Opportunity

Job Description: Position Description and Responsibilities: As a member of the Modeling and Simulation group, you will lead the design and conduct population exposure response modeling analysis to investigate relationships between drug exposure and safety, efficacy data for investigational new drugs preparing clinical exposure response reports for regulatory agencies, including the U.S. Food and drug Administration. Perform model based exposure response simulations to optimize the selection of dosing regimes that maximize efficacy and minimize adverse reactions. Characterize exposure response relationships in special patient population such as patients with renal or hepatic impairment using population exposure response approaches to ensure the proper labeling of dosing regimen, safety and efficacy. Develop novel modeling and simulation methods by integrating knowledge and techniques from multiple fields, including biology, clinical pharmacology, Education Requirements: Doctor of Philosophy degree in Pharmaceutical Sciences along with Three - Five years of experience in Strategic Exposure Response Modeling and Simulation, PKPD, SPlus, NONMEM or a related field. Experience Requirements: Strong oral and written communication skills necessary to formally present and report information internally and externally is required. The ability to work in a dynamic team oriented environment is essential. Jay Chapman Hughes and Associates [email protected] 704-333-5211 www.haallc.com The information contained in this electronic mail transmission is intended by Hughes and Associates for the use of the named individual or entity to which it is addressed and may contain information that is privileged or otherwise confidential. It is not intended for transmission to, or receipt by, any individual or entity other than the named addressee (or a person authorized to deliver it to the named addressee) except as otherwise expressly permitted in this electronic mail transmission. If you have received this electronic transmission in error, please delete it without copying or forwarding it, and notify the sender of the error by reply email.

PHARMACOKINETICIST and POBLATIONAL MODELLING Our client is an International Pharmaceutical Company located in Spain with headquarter in Barcelona, devoted to identifying, developing and marketing innovative therapeutic products. Reporting to the Head of Bioanalysis and ADME Development, will provide leadership in pharmacokinetic and poblational modelling to the assigned preclinical or clinical projects. Specific responsibilities include the planning and designing of pharmacokinetic studies, providing PK input into clinical reports, obtaining the PK properties of the drugs in development, and predicting their behaviour in humans. The requirements of the position are as follows: - BSc or PhD in Life Sciences. - Several years experience in the field of modelling and simulations of PK data. - Good command of standard software for PK analysis in the Pharmaceutical industry (WinNonlin, Nonmem, Adapt…) - Fluent in written and spoken English - Excellent interpersonal skills - Open to relocate to Barcelona. If you are interested in this opportunity, please send us an updated CV to pk align="justify">

Associate Director, PK/PD My client is a growing, dynamic biologics company located in the Mid-Atlantic, is looking for an experienced PK/PD Scientist to provide pharmacokinetic and pharmacodynamic expertise to pre-clinical and clinical project teams. Collaborate with team members from different disciplines in evaluating and developing clinical drug candidates. Apply PK /PD modeling for selection of dose and dosing schedule for pre- clinical and clinical studies. . Plan, design, analyze, interpret and report pharmacokinetic and pharmacodynamic data from pre -clinical and clinical studies . Perform population PK and PK/PD analysis and interpretation . Perform population PK, PD and PK/PD simulations . Perform PK/PD simulations and predict pre -clinical and clinical PK as appropriate . Interpret and present project related study results and recommendations to management and relevant project and therapy teams Requirements PhD, 6+ years eperience, biologics experience preferred. Interested in learning more? Call or email me; K.Davd Cadieu 609-882-8660 [email protected] K. David Cadieu KDC GROUP, INC. 609.882.8660 <mailto:[email protected]> [email protected] http://www.go-acop.org/ acop2009_logo http://www.go-acop.org/ 2 0 0 9 SPONSOR <<image002.jpg>>