dear NONMEM community,
I'd like to estimate the potential value of individual dose adaptations of
an anticancer drug by applying Bayesian POSTHOC (individual) estimates on a
previous model. As I have data on the interoccasion variability, I put "OCC"
into the table for the Bayesian run, but NONMEM seems not to accept two
occasions for POSTHOC-only:
""0DATA REC 31: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM
0DATA REC 51: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM""
I'd guess that >1 occasion should also work with POSTHOC-only, with an
adequate input of IOV and residual variability. Otherwise, it might be
necessary
to code two time-separate dosing events within one time-scale? Can anybody
explain?
thanks and kind regards,
Markus
my table looks like that:
-----------------------------------------------------------------------------------------------
C, ID, OCC, TIME, AMT, RATE, DV, CMT, MDV, EVID, AGE, BILI, BSA, SEX
--
Markus Joerger MD PhD
Department of Medical Oncology
Rorschacherstr. 95
9007 St. Gallen
Switzerland
[email protected]
[email protected]
phone: +41-765591070
fax: +41-714946368
001bayesian.res
Description:
Binary data
Bayesian estimates of multiple occasions
Dear Markus:
The error message indicated that you need to use EVID=4 to reset your system
in the second dose event.
Sam Liao
Pharmax Research Inc.
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of markus joerger
Sent: Thursday, June 03, 2010 8:20 AM
To: [email protected]
Subject: [NMusers] Bayesian estimates of multiple occasions
dear NONMEM community,
I'd like to estimate the potential value of individual dose adaptations of
an anticancer drug by applying Bayesian POSTHOC (individual) estimates on a
previous model. As I have data on the interoccasion variability, I put "OCC"
into the table for the Bayesian run, but NONMEM seems not to accept two
occasions for POSTHOC-only:
""0DATA REC 31: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM
0DATA REC 51: TIME DATA ITEM IS LESS THAN PREVIOUS TIME DATA ITEM""
I'd guess that >1 occasion should also work with POSTHOC-only, with an
adequate input of IOV and residual variability. Otherwise, it might be
necessary
to code two time-separate dosing events within one time-scale? Can anybody
explain?
thanks and kind regards,
Markus
my table looks like that:
----------------------------------------------------------------------------
-------------------
C, ID, OCC, TIME, AMT, RATE, DV, CMT, MDV, EVID, AGE, BILI, BSA, SEX
--
Markus Joerger MD PhD
Department of Medical Oncology
Rorschacherstr. 95
9007 St. Gallen
Switzerland
[email protected]
[email protected]
phone: +41-765591070
fax: +41-714946368