Dear all,
I have a question regarding the estimation and definition of the AUC in $DES.
For my survival model I need the estimated AUC in $DES AND in $ERROR as you can
see below. Looking in the output table NM estimated high values for AUC1 (from
$DES) for TIME=0 for each ID. Afterwards the estimates for AUC1 and AUC2 were
the same.
My question is, is this only a problem of NM to transfer/display parameters
defined in $DES in the output table or is the AUC1 calculated here wrong for
TIME=0?
Thanks a lot in advance and
best regard,
Friederike
$DES
DADT(1)= ...
CONC=A(1)/V
DADT(2)=CONC ; AUC
AUC1 = A(2)
DADT(3)=BLHAZ*EXP(BETA*AUC1)
$ERROR
AUC2=A(2) ; AUC
CUMHAZ = A(3) ; CUMULATIVE HAZARD
SURV = EXP(-CUMHAZ) ; SURVIVAL FUNCTION
IF(DV.EQ.1) THEN ; EVENT
HAZNOW = BLHAZ*EXP(BETA*AUC2) ; HAZARD RATE NOW
Y = HAZNOW*SURV
ELSE ; CENSORED
Y = SURV
ENDIF
$TABLE ... AUC1 AUC2
--------------------------------------
Friederike Kanefendt
PhD-student
University of Bonn
-Clinical Pharmacy-
An der Immenburg 4
D-53121 Bonn
Phone: +49 (0)228 73-5781
Fax: +49(0) 228 73-9757
[email protected]